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Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis
Authors: Manuel L. Merz; Veronika M. Shoba; Rajaiah Pergu; Zachary C. Severance; Dhanushka N. P. Munkanatta Godage; Arghya Deb; Hui Si Kwok; Prashant Singh; Sameek Singh; Jonathan B. Allen; Wenzhi Tian; Pallavi M. Gosavi; Santosh K. Chaudhary; Viktoriya Anokhina; Ellen L. Weisberg; N. Connor Payne; Yao He; Reilly Osadchey; Mrinal Shekhar; Ralph Mazitschek; Matthew G. Rees; Jennifer A. Roth; Qiang Cui; James D. Griffin; Brian B. Liau; Amit Choudhary
Journal: biorxiv
PubMed ID: 40661463
Doi: 10.1101/2025.06.13.659082
Products & Services: PCR Cloning and Subcloning   
Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis
Authors: Manuel L. Merz; Veronika M. Shoba; Rajaiah Pergu; Zachary C. Severance; Dhanushka N. P. Munkanatta Godage; Arghya Deb; Hui Si Kwok; Prashant Singh; Sameek Singh; Jonathan B. Allen; Wenzhi Tian; Pallavi M. Gosavi; Santosh K. Chaudhary; Viktoriya Anokhina; Ellen L. Weisberg; N. Connor Payne; Yao He; Reilly Osadchey; Mrinal Shekhar; Ralph Mazitschek; Matthew G. Rees; Jennifer A. Roth; Qiang Cui; James D. Griffin; Brian B. Liau; Amit Choudhary
Journal: biorxiv
PubMed ID: 40661463
Doi: 10.1101/2025.06.13.659082
Products & Services: PCR Cloning and Subcloning   
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj
Journal: Nature Chemical Biology
PubMed ID: 40542165
Doi: 10.1038/s41589-025-01929-w
Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity
Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu
Journal: Frontiers in cellular and infection microbiology
PubMed ID: 40270771
Doi: 10.3389/fcimb.2025.1560330
Machine learning-assisted substrate binding pocket engineering based on structural information
Authors: Xinglong Wang; Kangjie Xu; Xuan Zeng; Kai Linghu; Beichen Zhao; Shangyang Yu; Kun Wang; Shuyao Yu; Xinyi Zhao; Weizhu Zeng; Kai Wang; Jingwen Zhou
Journal: BRIEFINGS IN BIOINFORMATICS
PubMed ID: 39101501
Doi: 10.1093/bib/bbae381
Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes
Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu
Journal: Frontiers in pharmacology
PubMed ID: 40343007
Doi: 10.3389/fphar.2025.1562244
Products & Services: Protein Electrophoresis and Western   
H19 influenza A virus exhibits species-specific MHC-II receptor usage
Authors: Umut Karakus; Ignacio Mena; Jithesh Kottur; Sara S. El Zahed; Roc o Seoane; Soner Yildiz; Leanne Chen; Magdalena Plancarte; LeAnn Lindsay; Rebecca Halpin; Timothy B Stockwell; David E. Wentworth; Geert-Jan Boons; Florian Krammer; Silke Stertz; Walter Boyce; Robert P de Vries; Aneel K Aggarwal; Adolfo Garc a-Sastre
Journal: Cell Host & Microbe
PubMed ID: 38889725
Doi: 10.1016/j.chom.2024.05.018
H19 influenza A virus exhibits species-specific MHC-II receptor usage
Authors: Umut Karakus; Ignacio Mena; Jithesh Kottur; Sara S. El Zahed; Roc o Seoane; Soner Yildiz; Leanne Chen; Magdalena Plancarte; LeAnn Lindsay; Rebecca Halpin; Timothy B Stockwell; David E. Wentworth; Geert-Jan Boons; Florian Krammer; Silke Stertz; Walter Boyce; Robert P de Vries; Aneel K Aggarwal; Adolfo Garc a-Sastre
Journal: Cell Host & Microbe
PubMed ID: 38889725
Doi: 10.1016/j.chom.2024.05.018
Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity
Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu
Journal: Frontiers in cellular and infection microbiology
PubMed ID: 40270771
Doi: 10.3389/fcimb.2025.1560330
Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity
Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu
Journal: Frontiers in cellular and infection microbiology
PubMed ID: 40270771
Doi: 10.3389/fcimb.2025.1560330
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