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N-Terminal random curl-tandam α-helical peptide 7W: A potent antibacterial and anti-inflammatory dual-effect agent through tryptophan substitution

Authors: Jietao Lou, Xinyi Wu, Wenwen Ji, Jiaye Yu, Yanyan Xu, Wanyang Xiao, Weijie Lu, Kaiyun Xin, Tianbao Chen, Qidong Tang, Guang Liang, Yitian Gao, Di Wu

Journal: Eur J Med Chem

PubMed ID: 40319576

Doi: 10.1016/j.ejmech.2025.117686

Products & Services: Peptide Synthesis

Fullerol Initiates Stem Cell–Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling

Authors: Haoyang Liu, Yue Zhu, Weixu Chen, Renwang Sheng, Chuanquan Liu, Yuzhi Sun, Jia Liu, Mingyue Wang, Jun Lu, Jialin Chen, Wei Zhang

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.5c01731

Products & Services: Recombinant Proteins

Targeted Delivery of mRNA with Polymer−Lipid Nanoparticles for In Vivo Base Editing

Authors: Qimingxing Chen, Yan Chang, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen, Jianfeng Li

Journal: ACS Nano

PubMed ID: 39962883

Doi: 10.1021/acsnano.4c14041

Products & Services: Custom DNA/RNA Oligos Synthetic Guide RNA

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Authors: Anoop S Chauhan, Matthew J W Mackintosh, Joseph Cassar, Alexander J Lanz, Mohammed Jamshad, Hannah L Mackay, Alexander J Garvin, Alexandra K Walker, Satpal S Jhujh, Teresa Carlomagno, Aneika C Leney, Grant S Stewart, Joanna R Morris

Journal: nature COMMUNICATION

PubMed ID: 40229270

Doi: 10.1038/s41467-025-56974-9

Products & Services: Peptide Synthesis Monoclonal Antibody Services

Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates ﬁbrilinduced cellular stress

Authors: Greeshma Jain, Marina Trombetta-Lima, Irina Matlahov, Hennrique Taborda Ribas, Tingting Chen, Raffaella Parlato, Giuseppe Portale, Amalia M. Dolga & Patrick C. A. van der Wel

Journal: Nat Commun

PubMed ID: 40234398

Doi: 10.1038/s41467-025-58691-9

Products & Services: Plasmid DNA Preparation Catalog Antibodies

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors: Emre Fertan; Jeff Y. L. Lam; Giulia Albertini; Maarten Dewilde; Yunzhao Wu; Oluwatomi E. S. Akingbade; Dorothea B ken; Elizabeth A. English; Bart De Strooper; David Klenerman

Journal: Alzheimer's & Dementia

PubMed ID: 40237235

Doi: 10.1002/alz.70086

Products & Services: Protein and Antibody Isolation

The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

Authors: Andrea Iannucci, Davide Lacarbonara, Valeria Caneparo, Federica Castiglioni, Andrea Butticè, Stefano Raviola, Chiara Porta, Riccardo Miggiano, Ivan Zanoni, Marisa Gariglio, Marco De Andrea

Journal: iScience

PubMed ID: 40454096

Doi: 10.1016/j.isci.2025.112413

Products & Services: Mutagenesis Services

Synergistic impact of macrolide resistance and H3N2 infection on M. pneumoniae outbreak in children

Authors: Jiali Chen, Yingdan Wang, Juan Cheng, Yunping Ma, Xin Zhang, Xuezhou Bai, Palizhati Rehati, Huashun Cui, Fan Wu, Qiuhui Pan, Jinghe Huang

Journal: Microbiology Spectrum

PubMed ID: 39998323

Doi: 10.1128/spectrum.01844-24

Products & Services: Gene Synthesis

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Authors: Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T Hung, Robert M Stroud

Journal: Nature Communications

PubMed ID: 40169593

Doi: 10.1038/s41467-025-58133-6

Products & Services: Mutagenesis Services

Structural basis for allosteric modulation of M. tuberculosis proteasome core particle

Authors: Madison Turner, Adwaith B. Uday, Algirdas Velyvis, Enrico Rennella, Natalie Zeytuni & Siavash Vahidi

Journal: Nature Communications

PubMed ID: 40169579

Doi: 10.1038/s41467-025-58430-0

Products & Services: Peptide Synthesis