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Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy

Authors: Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng

Journal: Advanced Science

PubMed ID: 40874418

Doi: 10.1002/advs.202511144

Products & Services: Protein and Antibody Isolation

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Authors: Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu

Journal: Nature Communications

PubMed ID: 40790299

Doi: doi.org/10.1038/s41467-025-62870-z

Products & Services: Gene Synthesis

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-DietInduced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice

Authors: Shuai Wang, Shuting Liu, Ting He, Huanming Shen, Chunli Mo, Yu Zhu, Wenlo, Weihua Li, Jian Zhang

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 40810347

Doi: doi.org/10.1021/acs.jafc.5c02577

Products & Services: Catalog Antibodies

Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration

Authors: An Lao, Yiting Sun, Weiqi Li, Yu Zhuang, Ziyang Liu, Chenci Xu, Xiangbing Wu, Linhu Ge, Kaili Lin, Jianyong Wu, Jing Mao, Jiaqiang Liu

Journal: Biomaterials

PubMed ID: 40916241

Doi: 10.1016/j.biomaterials.2025.123656

Products & Services: Protein and Antibody Isolation

Optimised modular anti‐FLAG CAR T cells for solid tumor therapy

Authors: Xiaomeng Zhang, Rachel Xu, Dmitry Zorin, Evan G Pappas, Jiawei Tang, Yuchen Bai, Vicky M Qin, Bianca von Scheidt, Ruihong Huang, Weronika Kulakowska, Charbel Darido, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal: Clinical & Translational Immunology

PubMed ID: 40851786

Doi: 10.1002/cti2.70046

Products & Services: Recombinant Proteins Gene Synthesis

A receptor antagonist counterbalances multiple systemin phytocytokines in tomato

Authors: Lei Wang, Louis-Philippe Maier, Nga Pham, Yan L Wang, Xu Wang, Andreas Schaller, Judith Fliegmann, Matthias Erb, Thomas Boller, Georg Felix

Journal: Cell

PubMed ID: 40845839

Doi: 10.1016/j.cell.2025.07.044

Products & Services: Peptide Synthesis

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Authors: Javier Moral-Sanz; Isabel Fern ndez-Carrasco; Valentina Ramponi; Amanda Garrido; Izhar Karbat; Pablo Cabezas-Sainz; Esperanza Rivera-de-Torre; Osama Elsallabi; Roberto Mart n-Hern ndez; Jos L. L pez-Aceituno; Nathan L. Price; Laura Sanchez; Gonzalo Colmenarejo; lvaro Mart nez-del-Pozo; Irina Vetter; Angel Cogolludo; Francisco Perez-Vizcaino; Jorge Del-Pozo; Eitan Reuveny; Manuel A. Fern ndez-Rojo; Paul D. Robbins; Rafael de Cabo; Manuel Serrano; Maria P. Ikonomopoulou

Journal: Nature Aging

PubMed ID: 41526742

Doi: 10.1038/s43587-025-01030-w

Products & Services: PCR Cloning and Subcloning

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Journal: Nature Aging

PubMed ID: 41526742

Doi: 10.1038/s43587-025-01030-w

Products & Services: PCR Cloning and Subcloning

AI-Guided Dual Strategy for Peptide Inhibitor Design Targeting Structural Polymorphs of -Synuclein Fibrils

Authors: Jinfang Duan; Haoyu Zhang; Chuanqi Sun

Journal: Cells

PubMed ID: 41369409

Doi: 10.3390/cells14231921

Products & Services: Peptide Synthesis

A Novel Fluorescence Polarization Binding Assay for the Main Protease (M pro ) of SARS-CoV 2

Authors: Mackenzie K. Wyllie; Rayhan G. Biswas; Jyoti Vishwakarma; Morgan A. Esler; Joseph A. Rollie; Hideki Aihara; Reuben S. Harris; Daniel A. Harki

Journal: ACS pharmacology & translational science

PubMed ID: 41262570

Doi: 10.1021/acsptsci.5c00463