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Structure-based lead optimization of enterovirus D68 2A protease inhibitors

Authors: Bin Tan; Chang Liu; Kan Li; Prakash Jadhav; George Lambrinidis; Lan Zhu; Linda Olson; Haozhou Tan; Yu Wen; Antonios Kolocouris; Wei Liu; Jun Wang

Journal: Journal of Medicinal Chemistry

PubMed ID: 37857371

Doi: 10.1021/acs.jmedchem.3c00995

A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Authors: Thu-Thuy Nguyen; Tae Heung Kim; Emily Bencosme-Cuevas; Jacquie Berry; Alex Samuel Kiarie Gaithuma; Moiz Ashraf Ansari; Tae Kwon Kim; Lucas Tirloni; Zeljko Radulovic; James J. Moresco; John R. Yates; Albert Mulenga

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services

SMAD3 and p300 complex scaffolding by long non-coding RNA LIMD1-AS1 promotes TGF-β-induced breast cancer cell plasticity

Authors: Chuannan Fan， Davy Cats， Miriam Selle， Olga Khorosjutina， Soniya Dhanjal， Bernhard Schmierer， Hailiang Mei， Peter Ten Dijke， Qian Wang

Journal: Nucleic Acids Research

PubMed ID: 40889156

Doi: 10.1093/nar/gkaf841

Products & Services: CRISPR Services

Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila

Authors: Chongyang Li, Zhe Meng, Qiuju Wen, Wenjuan Yang, Yaqian Xu, Yuening Lyu, Yile Guo, Tong Lyu, Dan Shen, Kun Dou

Journal: Nucleic Acids Research

PubMed ID: 40966519

Doi: 10.1093/nar/gkaf903

OLD amputates the anticodon arm of tRNAs during P2–Lambda interference

Authors: Apurva A Govande, Brian D Matibag, Irem Ünlü, Eric J Wolf, Molly R Sargen, Brooke Ramsey, Sangjin Kim, Sophie Helaine, Ivan R Corrêa Jr, Hoong Chuin Lim

Journal: Nucleic Acids Research

PubMed ID: 40966496

Doi: 10.1093/nar/gkaf874

Products & Services: Gene Services

A NanoLock-enabled, Craspase-based strategy for highly sensitive RNA detection

Authors: Yumeng Xiao, Junyu Chen, Xincan Hou, Hongwei Wang, Kundi Zhang, Sujuan Xu, Tao Jiang, Yangao Huo, Fengyu Zhang, Lichuan Gu

Journal: Nucleic Acids Research

PubMed ID: 40966498

Doi: 10.1093/nar/gkaf907

Products & Services: Gene Services

Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

Authors: Edgar J. Soto-Moreno, Nourhan N. Ali, Florian Küllmer, Veselin Nasufovic, Michaela Frolikova, Olga Tepla, Jaromir Masata, Dirk Trauner, Amanda A. Patterson, Hans-Dieter Arndt, Katerina Komrskova, Magdalena Zernicka-Goetz, David M. Glover & Ahmed Z. Balboula

Journal: Nature Communications

PubMed ID: 40973727

Doi: 10.1038/s41467-025-63586-w

Products & Services: Gene Services

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

Authors: Canqi Cui, Danielle C Leander, Sarah M Gray, Kimberley El, Alex Chen, Paul A Grimsrud, Jessica O Becker, Austin Taylor, Guo-Fang Zhang, Kyle W Sloop, C Bruce Verchere, Andrew N Hoofnagle, David A D'Alessio, Jonathan E Campbell

Journal: SCIENCE ADVANCES

PubMed ID: 40971442

Doi: 10.1126/sciadv.ady8048

Planthopper protein Nlsp5 is essential for salivary sheath formation and acts as a HAMP inducing plant resistance to insects

Authors: Liangxuan Qi, Jing Li, Han Wang, Shuai Li, Lei Yang, Jichao Fang, Rui Ji

Journal: Plant Biotechnology Journal

PubMed ID: 40546084

Doi: DOI10.1111/pbi.70223

Products & Services: Polyclonal Antibody Services

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects Against In Vivo Infection via the Induction of Broad-Spectrum PRRSV Neutralization

Authors: Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A Hiscox, James P Stewart, Yani Sun, Qin Zhao

Journal: Advanced Science

PubMed ID: 40919718

Doi: 10.1002/advs.202508875

Products & Services: Molecular Biology Reagents