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Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery

Authors: Lingling Shen; Jian Fang; Lulu Liu; Fei Yang; Jeremy L. Jenkins; Peter S. Kutchukian; He Wang

Journal: Journal of Cheminformatics

PubMed ID: 38515171

Doi: 10.1186/s13321-024-00829-w

Products & Services: Peptide Synthesis

Breaking the cancer code: a novel DNA minicircle to disable STAT3 in ovarian cancer cells SKOV3

Authors: Adina-Gabriela Vasilescu; Andrei-Mihai Vasilescu; Livia Elena Sima; Natalia Baran; tefan-Eugen Szedlacsek

Journal: Frontiers in pharmacology

PubMed ID: 41031165

Doi: 10.3389/fphar.2025.1673427

Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance

Authors: Vincent N. Azzolino; Ala M. Shaqra; Akbar Ali; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: Viruses

PubMed ID: 39339895

Doi: 10.3390/v16091419

Products & Services: Peptide Synthesis

Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery

Authors: Lingling Shen; Jian Fang; Lulu Liu; Fei Yang; Jeremy L. Jenkins; Peter S. Kutchukian; He Wang

Journal: Journal of Cheminformatics

PubMed ID: 38515171

Doi: 10.1186/s13321-024-00829-w

Products & Services: Peptide Synthesis

Breaking the cancer code: a novel DNA minicircle to disable STAT3 in ovarian cancer cells SKOV3

Authors: Adina-Gabriela Vasilescu; Andrei-Mihai Vasilescu; Livia Elena Sima; Natalia Baran; tefan-Eugen Szedlacsek

Journal: Frontiers in pharmacology

PubMed ID: 41031165

Doi: 10.3389/fphar.2025.1673427

Breaking the cancer code: a novel DNA minicircle to disable STAT3 in ovarian cancer cells SKOV3

Authors: Adina-Gabriela Vasilescu; Andrei-Mihai Vasilescu; Livia Elena Sima; Natalia Baran; tefan-Eugen Szedlacsek

Journal: Frontiers in pharmacology

PubMed ID: 41031165

Doi: 10.3389/fphar.2025.1673427

Selective fluorination of Fc glycans enhances antibody-mediated effector functions

Authors: Xianyang Wang; Margaryta Gomozkova; Siqi Li; Biswarup Banerjee; Guanghui Zong; Dominique Missiakas; Lai-Xi Wang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41849397

Doi: 10.1073/pnas.2530653123

Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14

Authors: Juan C Moreno, Umar F Shahul Hameed, Aparna Balakrishna, Abdugaffor Ablazov, Kit Xi Liew, Muhammad Jamil, Jianing Mi, Kawthar Alashoor, Alexandre de Saint Germain, Stefan T Arold, Salim Al-Babili

Journal: Nature Communications

PubMed ID: 41038837

Doi: 10.1038/s41467-025-63845-w

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling

Authors: Jung Seok Hwang, JiHoon Kang, Jaehyun Kim, Kiyoung Eun, Sophia West, Hannah E Bacho, Vanessa Avalos, Sydney Shuff, Dong M Shin, Nabil F Saba, Kelly R Magliocca, Cheng-Kui Qu, Haian Fu, Suresh S Ramalingam, Andrey A Ivanov, Taro Hitosugi, Sumin Kang

Journal: Nature Communications

PubMed ID: 41062483

Doi: 10.1038/s41467-025-63892-3

Discovery of a Serine-Directed Chemical Reaction for Site-Specific Protein Modification via Phage Display Screening

Authors: Yingjie Lei, Kai Zhao, Mengzhun Guo, Liang Guo, Jinfeng Chen, Mengjiao Li, Dandan Liu, Kai Chen, Jiahao Mei, Tian Li, Bing Yang, Jing Huang, Bobo Dang

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 41108661

Doi: doi.org/10.1002/anie.202514412

Products & Services: Protein and Antibody Isolation