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A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

Authors: Mebratu A Bitew, Tatiana C Paredes-Santos, Parag Maru, Shruthi Krishnamurthy, Yifan Wang, Lamba O Sangaré, Samuel Duley, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Jeroen P J Saeij

Journal: Nature Communications

PubMed ID: 41407671

Doi: 10.1038/s41467-025-66137-5

Products & Services: Protein and Antibody Isolation

Efficient high-precision transgene knock-in by Recombinases (Redα/β)-enhanced DNA integration-CRISPR-Cas9 (RED-CRISPR)

Authors: Wenqing Li, Senquan Liu, Xiaoyu Fang, Jiaqi Zou, Qin Jiang, Xiaolin Min, Xiaoli Zhu, Yuzhu Cao, Xiaoxiao Gao, Wenjie Han, Muhammad Azhar, Xuemei Xing, Fudong Li, Youming Zhang, Hongbin Liu, Linzhao Cheng, Chengkun Wang, Jianqiang Bao

Journal: Nature Communications

PubMed ID: 41365890

Doi: 10.1038/s41467-025-67239-w

Products & Services: Catalog IVT RNA products

Structural insights into kainate receptor desensitization

Authors: Changping Zhou, Guadalupe Segura-Covarrubias, Nami Tajima

Journal: Nature Communications

PubMed ID: 41365859

Doi: 10.1038/s41467-025-65920-8

Gene-corrected regulatory T cell therapy for IL2RA deficiency

Authors: Alvin S Ha, Nechama Kalter, Michael Rosenberg, Luis A Acevedo, Brianna Liang, Weihong Liu, Sreenivasan Paruthiyil, Meenal Sinha, Alexander Vu, Vinh Nguyen, Zhongxia Qi, Netravathi Krishnappa, Jinna Shu, Jingwei Yu, Jason Catanzaro, Jeffrey A Bluestone, Qizhi Tang, Fyodor D Urnov, Alexander Marson, Ayal Hendel, Kevan C Herold, Brian R Shy, Jonathan H Esensten

Journal: Molecular Therapy

PubMed ID: 41376159

Doi: 10.1016/j.ymthe.2025.12.004

Products & Services: Molecular Biology Reagents

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion

Authors: Guosong Wang, Yu Li, Chongxin Wu, Tian Chen, Mengxuan Gui, Yue Zeng, Hui Sun, Kaiyun Chen, Xiangfeng Xi, Yanbo Yang, Yuchen Jiang, Yanan Jiang, Liqin Liu, Chengyu Yang, Jiarui Xin, Caihong Liu, Yiyi Li, Ningning Huo, Yang Huang, Lina Lin, Hai Yu, Chenghao Huang, Quan Yuan, Shaowei Li, Kegong Tian, Qingbing Zheng, Ningshao Xia, Yixin Chen

Journal: Nature Communications

PubMed ID: 41402251

Doi: 10.1038/s41467-025-66099-8

Products & Services: Antibody Modification and Purification Services

SnRK2.5-mediated phosphorylation of PIN2 links osmotic stress signaling with auxin dependent root adaptive growth in Arabidopsis

Authors: Shujuan Zhang, Zilong Cui, Yu Gao, Qi Liao, Wenyan Li, Siqi Yuan, Zhuomeng Li, Xinwen Zhang, Kai Ding, Wenjing Zhang, Like Shen, Jörg Kudla, Wenhua Zhang, Jing Zhang, Qun Zhang

Journal: Molecular Plant

PubMed ID: 41353562

Doi: 10.1016/j.molp.2025.12.002

Products & Services: Protein and Antibody Isolation Catalog Antibodies

Discovery of novel pyrrolidine-2,5-dione scaffold PICK1 PDZ inhibitors as anti-ischemic stroke agents

Authors: Yichen Jiang, Qi Liu, Ting Zhu, Ruiguo Liang, Yujiao Qin, Xiya Guo, Jiacheng Wang, Ping Li, Jie Zhou, Han Ju, Mingxin Dong

Journal: European Journal of Medicinal Chemistry

PubMed ID: 41386205

Doi: 10.1016/j.ejmech.2025.118410

Products & Services: Plasmid DNA Preparation

Native cell niche-inspired multiorder nanoassemblies orchestrate integrated interaction networks to guide muscle regeneration

Authors: Peng Lou, Yizhuo Wang, Yimeng Zhang, Xiyue Zhou, Lan Li, Shuyun Liu, Meihua Wan, Yanrong Lu, Jingping Liu