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页码: 122/5357 每页显示数量

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Authors: Anoop S Chauhan, Matthew J W Mackintosh, Joseph Cassar, Alexander J Lanz, Mohammed Jamshad, Hannah L Mackay, Alexander J Garvin, Alexandra K Walker, Satpal S Jhujh, Teresa Carlomagno, Aneika C Leney, Grant S Stewart, Joanna R Morris

Journal: nature COMMUNICATION

PubMed ID: 40229270

Doi: 10.1038/s41467-025-56974-9

Products & Services: Peptide Synthesis Monoclonal Antibody Services

Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates ﬁbrilinduced cellular stress

Authors: Greeshma Jain, Marina Trombetta-Lima, Irina Matlahov, Hennrique Taborda Ribas, Tingting Chen, Raffaella Parlato, Giuseppe Portale, Amalia M. Dolga & Patrick C. A. van der Wel

Journal: Nat Commun

PubMed ID: 40234398

Doi: 10.1038/s41467-025-58691-9

Products & Services: Plasmid DNA Preparation Catalog Antibodies

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors: Emre Fertan; Jeff Y. L. Lam; Giulia Albertini; Maarten Dewilde; Yunzhao Wu; Oluwatomi E. S. Akingbade; Dorothea B ken; Elizabeth A. English; Bart De Strooper; David Klenerman

Journal: Alzheimer's & Dementia

PubMed ID: 40237235

Doi: 10.1002/alz.70086

Products & Services: Protein and Antibody Isolation

Exploring the potential of selective FKBP51 inhibitors on melanoma: an investigation of their in vitro and in vivo effects

Authors: Laura Marrone; Valeria Di Giacomo; Chiara Malasomma; Marialuisa Alessandra Vecchione; Felix Hausch; Massimiliano Cacace; Lucia D Esposito; Martina Tufano; Paolo D Arrigo; Maria Fiammetta Romano; Simona Romano

Journal: Cell death discovery

PubMed ID: 40180895

Doi: 10.1038/s41420-025-02430-y

Products & Services: Custom Vector Construction

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

Authors: Chunlong Ma; Michael Dominic Sacco; Zilei Xia; George Lambrinidis; Julia Alma Townsend; Yanmei Hu; Xiangzhi Meng; Tommy Szeto; Mandy Ba; Xiujun Zhang; Maura Gongora; Fushun Zhang; Michael Thomas Marty; Yan Xiang; Antonios Kolocouris; Yu Chen; Jun Wang

Journal: ACS central science

PubMed ID: 34341772

Doi: 10.1021/acscentsci.1c00519

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Authors: Martina Tuttolomondo; Stephanie Thuy Duong Pham; Mikkel Green Terp; Virginia Cend n Castillo; Nazmie Kalisi; Stefan Vogel; Niels Langkj r; Ulla Melchior Hansen; Helge Thisgaard; Henrik Daa Schr der; Yaseelan Palarasah; Henrik J rn Ditzel

Journal: Molecular therapy. Nucleic acids

PubMed ID: 38939051

Doi: 10.1016/j.omtn.2024.102227

Products & Services: Peptide Synthesis

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Journal: Molecular therapy. Nucleic acids

PubMed ID: 38939051

Doi: 10.1016/j.omtn.2024.102227

Products & Services: Peptide Synthesis

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Journal: Molecular therapy. Nucleic acids

PubMed ID: 38939051

Doi: 10.1016/j.omtn.2024.102227

Products & Services: Peptide Synthesis

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Journal: Molecular therapy. Nucleic acids

PubMed ID: 38939051

Doi: 10.1016/j.omtn.2024.102227

Products & Services: Peptide Synthesis

Eukaryotic Initiation Factor 2 Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens

Authors: Heather A. Walters; Brenda H. Welter; Harrison C. Moss; Martha A. Villano; Ronny Orobio-Hurtado; William J. Sullivan; Lesly A. Temesvari

Journal: mSphere

PubMed ID: 35638357

Doi: 10.1128/msphere.00131-22

Products & Services: Plasmid DNA Preparation