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Phosphorylation dependent charge block regulate the relaxation of nuclear speckle networks

Authors: Mengjun Zhang, Zhuang Gu, Yingtian Sun, Yichen Dong, Junlin Chen, Li Shu, Suibin Ma, Jierui Guo, Yuhang Liang, Qingming Qu, Ning Fang, Chuan-Qi Zhong, Yifan Ge, Zhongwen Chen, Shaohui Huang, Xin Zhang, Bo Wang

Journal: Mol Cell

PubMed ID: 40233760

Doi: 10.1016/j.molcel.2025.03.016

Products & Services: Protein and Antibody Isolation

Polyarginine Peptide R11 Actin Interaction Induces a Domino Effect on Cytoskeleton Remodeling to Suppress Bladder Cancer Metastasis

Authors: Zhenghong Liu; Chuanzan Zhou; Wentao Xu; Dahong Zhang; Bin Zheng; Facai Zhang; Xiaowen Qin; Heng Wang; Yixuan Mou; Yang Liu; Haichang Li; Jing Quan; Li Sun; Yiyang Chen; Chenkai Wang; Xuanyi Zhou; Xinyi Chen; Hong Tang; Dingyi Liu; Wenyan Zuo; Dechao Feng; Pu Zhang; Qi Zhang

Journal: RESEARCH

PubMed ID: 41624794

Doi: 10.34133/research.1109

Products & Services: Protein Electrophoresis and Western

Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates ﬁbrilinduced cellular stress

Authors: Greeshma Jain, Marina Trombetta-Lima, Irina Matlahov, Hennrique Taborda Ribas, Tingting Chen, Raffaella Parlato, Giuseppe Portale, Amalia M. Dolga & Patrick C. A. van der Wel

Journal: Nat Commun

PubMed ID: 40234398

Doi: 10.1038/s41467-025-58691-9

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Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors: Emre Fertan; Jeff Y. L. Lam; Giulia Albertini; Maarten Dewilde; Yunzhao Wu; Oluwatomi E. S. Akingbade; Dorothea B ken; Elizabeth A. English; Bart De Strooper; David Klenerman

Journal: Alzheimer's & Dementia

PubMed ID: 40237235

Doi: 10.1002/alz.70086

Products & Services: Protein and Antibody Isolation

S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2

Authors: Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang

Journal: Advanced Science

PubMed ID: 40171943

Doi: 10.1002/advs.202416481

Products & Services: Protein and Antibody Isolation

A predatory gene drive for targeted control of self-transmissible plasmids

Authors: Ryan Tsoi, Hye-In Son, Grayson S Hamrick, Katherine Tang, Jonathan H Bethke, Jia Lu, Rohan Maddamsetti, Lingchong You

Journal: SCIENCE ADVANCES

PubMed ID: 40173243

Doi: 10.1126/sciadv.ads4735

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Supra-second tracking and live-cell karyotyping reveal principles of mitotic chromosome dynamics

Authors: Rumen Stamatov, Sonya Uzunova, Yoana Kicheva, Maria Karaboeva, Tavian Blagoev, Stoyno Stoynov

Journal: Nature Cell Biology

PubMed ID: 40185948

Doi: 10.1038/s41556-025-01637-6

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Engineered nucleocytosolic vehicles for loading of programmable editors

Authors: Julian Geilenkeuser, Niklas Armbrust, Emily Steinmaßl, Samuel W Du, Sebastian Schmidt, Eva Maria Hildegard Binder, Yuchun Li, Niklas Wilhelm Warsing, Stephanie Victoria Wendel, Florian von der Linde, Elisa Marie Schiele, Xiya Niu, Luisa Stroppel, Oleksandr Berezin, Tobias Heinrich Santl, Tanja Orschmann, Keith Nelson, Christoph Gruber, Grazyna Palczewska, Carolline Rodrigues Menezes, Eleonora Risaliti, Zachary J Engfer, Naile Koleci, Andrea Schmidts, Arie Geerlof, Krzysztof Palczewski, Gil Gregor Westmeyer, Dong-Jiunn Jeffery Truong

Journal: Cell

PubMed ID: 40209705

Doi: 10.1016/j.cell.2025.03.015

Products & Services: Protein Electrophoresis and Western

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage

Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T. Johnson, Francesca Tonelli, Lin Shao, Gabriel Talaia, Dario R. Alessi, Shawn M. Ferguson & Pietro De Camilli

Journal: Nature Cell Biology

PubMed ID: 40211074

Doi: 10.1038/s41556-025-01653-6

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Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses

Authors: Sebastian G. Huayamares, Liming Lian, Regina Rab, Yuning Hou, Afsane Radmand, Hyejin Kim, Ryan Zenhausern, Bhagelu R. Achyut, Melissa Gilbert Ross, Melissa P. Lokugamage, David Loughrey, Hannah E. Peck, Elisa Schrader Echeverri, Alejandro J. Da Silva Sanchez, Aram Shajii, Andrea Li, Karen E. Tiegreen, Philip J. Santangelo, Eric J. Sorscher & James E. Dahlman

Journal: Nature Communications

PubMed ID: 40221395

Doi: 10.1038/s41467-025-58548-1

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