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页码: 101/5356 每页显示数量

Enhancement of CRISPR-Cas12a system through universal circular RNA design

Authors: Jiaqi Wang, Wei Zhang, Wentao Li, Qinyuan Xie, Ziyu Zang, Chaoxing Liu

Journal: Cell Reports Methods

PubMed ID: 40527291

Doi: 10.1016/j.crmeth.2025.101076

Products & Services: Molecular Biology Reagents

YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

Products & Services: Protein and Antibody Isolation Protein and Antibody Isolation

RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

Products & Services: Catalog Antibodies

Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Authors: Kewei Rong, Dezheng Wang, Xiting Pu, Cheng Zhang, Pu Zhang, Xiankun Cao, Jinglin Zheng, Xiao Yang, Kexin Liu, Lei Shi, Yin Li, Peixiang Ma, Dan Ye, Jie Zhao, Pu Wang, An Qin

Journal: Bone Research

PubMed ID: 40500265

Doi: 10.1038/s41413-025-00437-w

Products & Services: Protein and Antibody Isolation

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity

Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu

Journal: Frontiers in cellular and infection microbiology

PubMed ID: 40270771

Doi: 10.3389/fcimb.2025.1560330

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Constitutive down-regulation of liguleless alleles in sorghum drives increased productivity and water use efficiency

Authors: Nikhil Jaikumar, Truyen Quach, Zhengxiang Ge, Natalya Nersesian, Shirley J Sato, Scott M McCoy, Ming Guo, Andrew D B Leakey, Stephen P Long, Tom Elmo Clemente

Journal: Plant Biotechnology Journal.

PubMed ID: 40452217

Doi: 10.1111/pbi.70150

Products & Services: Gene Synthesis