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AI-Guided Dual Strategy for Peptide Inhibitor Design Targeting Structural Polymorphs of -Synuclein Fibrils

Authors: Jinfang Duan; Haoyu Zhang; Chuanqi Sun

Journal: Cells

PubMed ID: 41369409

Doi: 10.3390/cells14231921

Products & Services: Peptide Synthesis

Identification of 14-3 3 Proteins as Binding Partners of TRP Channels

Authors: Nicol s Pe a-Vilches; Mariela Gonz lez-Avenda o; Nicole Soto-Garc a; Diego Maureira; Ian Silva; Javiera Avil s; El as Manr quez-Ben tez; Exequiel Medina; Oscar Cerda; Pablo Galaz-Davison; Ariela Vergara-Jaque

Journal: Journal of chemical information and modeling

PubMed ID: 41839059

Doi: 10.1021/acs.jcim.6c00092

DUX4 is a multifunctional factor priming human embryonic genome activation

Authors: Sanna Vuoristo; Shruti Bhagat; Christel Hyd n-Granskog; Masahito Yoshihara; Lisa Gawriyski; Eeva-Mari Jouhilahti; Vipin Ranga; Mahlet Tamirat; Mikko Huhtala; Ida Kirjanov; Sonja Nyk nen; Kaarel Krjut kov; Anastassius Damdimopoulos; Jere Weltner; Kosuke Hashimoto; Ga lle Recher; Sini Ezer; Priit Paluoja; Pauliina Paloviita; Yujiro Takegami; Ai Kanemaru; Karolina Lundin; Tomi T. Airenne; Timo Otonkoski; Juha S. Tapanainen; Hideya Kawaji; Yasuhiro Murakawa; Thomas R. B rglin; Markku Varjosalo; Mark S. Johnson; Timo Tuuri; Shintaro Katayama; Juha Kere

Journal: iScience

PubMed ID: 35402882

Doi: 10.1016/j.isci.2022.104137

Products & Services: Peptide Synthesis

Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI

Authors: Shengnan Li, Zhaoliang Shan, Guochun Zhao, Yuwei Li, Minghui Du, Xiuxiu Ti, Yuxue Gao, Wenting Li, Hui Zuo, Yan Wang, Qing Zhang

Journal: Nature Communications

PubMed ID: 40774949

Doi: 10.1038/s41467-025-62147-5.

Products & Services: Catalog Antibodies

Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA

Authors: De-Ping Wang, Rong Zhao, Wen-Shu Hu, Hai-Ning Li, Ji-Min Cao, Xin Zhou, Ye Xiang

Journal: Nature Communications

PubMed ID: 40775214

Doi: 10.1038/s41467-025-62609-w.

Products & Services: Protein and Antibody Isolation

Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling

Authors: Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu

Journal: Advanced Science

PubMed ID: 40789101

Doi: 10.1002/advs.202509846

Products & Services: Mutagenesis Services

Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease

Authors: Runchuan Yan, Yan Zhang, Jingjing Zhang, Xiangyi Zhang, Yue Han, Mengfei Wang, Dan Wang, Shengnan Huang, Wei Liu, Qi Shi, Xiaoping Dong, Wen-Quan Zou, Zhen Li, Jiyan Ma

Journal: SCIENCE ADVANCES

PubMed ID: 40768577

Doi: 10.1126/sciadv.adw6867

Products & Services: Recombinant Antibody Expression

Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious

Authors: Jiří Holoubek, Jiří Salát, Milos Matkovic, Petr Bednář, Pavel Novotný, Martin Hradilek, Taťána Majerová, Ebba Rosendal, Luděk Eyer, Andrea Fořtová, Michaela Beránková, Lesley Bell-Sakyi, Anna K. Överby, Andrea Cavalli, Massimiliano Bonomi, Félix A. Rey, Daniel Růžek

Journal: Nature Communications

PubMed ID: 40796726

Doi: 10.1038/s41467-025-62750-6.

Products & Services: PCR Cloning and Subcloning

Quantifying collective interactions in biomolecular phase separation

Authors: Hannes Ausserwöger, Ella de Csilléry, Daoyuan Qian, Georg Krainer, Timothy J Welsh, Tomas Sneideris, Titus M Franzmann, Seema Qamar, Nadia A Erkamp, Jonathon Nixon-Abell, Mrityunjoy Kar, Peter St George-Hyslop, Anthony A Hyman, Simon Alberti, Rohit V Pappu, Tuomas P J Knowles

Journal: Nature Communications

PubMed ID: 40830100

Doi: 10.1038/s41467-025-62437-y.

Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy

Authors: Ying Wang, Jiayao Yan, Lin Li, Tianran Chen, Jingyi Guo, Lei Lei, Siwen Wu, Lijing Zhu, Xiaotong Chen, Baorui Liu

Journal: Nature Communications

PubMed ID: 40849430

Doi: 10.1038/s41467-025-63269-6.

Products & Services: Recombinant Proteins