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Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Authors: Lingling Geng, Jiale Ping, Ruochen Wu, Haoteng Yan, Hui Zhang, Yuan Zhuang, Taixin Ning, Jun Wang, Chuqian Liang, Jiachen Zhang, Qingqing Chu, Jing Zhang, Yifan Wen, Yaobin Jing, Shuhui Sun, Qin Qiao, Qian Zhao, Qianzhao Ji, Shuai Ma, Yusheng Cai, Yandong Zheng, Zhiran Zou, Zhiqing Diao, Mingheng Li, Hao Zhang, Jianli Hu, Liangzheng Fu, Wang Kang, Ruijun Bai, Hongkai Zhao, Sheng Zhang, Yingjie Ding, Jinghui Lei, Wei Wang, Yun Ji, Bo Gou, Guoqiang Sun, Jian Yin, Pengze Yan, Hao Li, Zehua Wang, Shikun Ma, Zunpeng Liu, Hezhen Shan, Qiaoran Wang, Tianling Cao, Shanshan Yang, Cui Wang, Ping Yang, Yanling Fan, Yanxia Ye, Jinghao Hu, Mengmeng Jiang, Ye Wang, Kan Liu, Yujing Li, Yuanxiang Li, Jingyi Li, Weimin Ci, Zi-Bing Jin, Xiaobing Fu, Xu Zhang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Si Wang, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Journal: Cell

PubMed ID: 40570836

Doi: 10.1016/j.cell.2025.06.001

Products & Services: Synthetic Guide RNA

RING-Between-RING-Type E3 Ligase Ariadne-Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein

Authors: Wenli Li, Chenchen Zhong, Jiangning Duan, Changyi Zhan, Zhaolei Li, Xinyu Zhang, Dingliang Zhang, Deshui Liu, Zhiyan Wen, Xiaofei Zhao, Meng Yang, Dawei Li, Yongliang Zhang

Journal: Advanced Science

PubMed ID: 40908568

Doi: 10.1002/advs.202509942

Functional characterisation of missense ceruloplasmin variants and real-world prevalence assessment of Aceruloplasminemia using population data

Authors: Nicole Ziliotto; Sara Lencioni; Martina Cirinciani; Alan Zanardi; Massimo Alessio; Giulia Sold ; Eleonora Da Pozzo; Rosanna Asselta; Andrea Caricasole

Journal: EBioMedicine

PubMed ID: 40043514

Doi: 10.1016/j.ebiom.2025.105625

Functional characterisation of missense ceruloplasmin variants and real-world prevalence assessment of Aceruloplasminemia using population data

Authors: Nicole Ziliotto; Sara Lencioni; Martina Cirinciani; Alan Zanardi; Massimo Alessio; Giulia Sold ; Eleonora Da Pozzo; Rosanna Asselta; Andrea Caricasole

Journal: EBioMedicine

PubMed ID: 40043514

Doi: 10.1016/j.ebiom.2025.105625

A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Authors: Thu-Thuy Nguyen; Tae Heung Kim; Emily Bencosme-Cuevas; Jacquie Berry; Alex Samuel Kiarie Gaithuma; Moiz Ashraf Ansari; Tae Kwon Kim; Lucas Tirloni; Zeljko Radulovic; James J. Moresco; John R. Yates; Albert Mulenga

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services

A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services

Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activation

Authors: Kamalakshi Deka, Jean-Michel Carter, Akash Bahai, Daniel Aron Ang, Nicholas Sim, Hooi Yan Chong, Guan Hwee Bernard Lee, Suet Mien Tan, Wee Joo Chng, Dennis Kappei, Yinghui Li

Journal: Nature Communications

PubMed ID: 40890111

Doi: 10.1038/s41467-025-63256-x.

Products & Services: Gene Services

Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors

Authors: Rupert Klaushofer, Konstantin Bloch, Luisa Susanna Eder, Simone Marzaro, Mario Schubert, Eva Böttcher-Friebertshäuser, Hans Brandstetter, Sven O Dahms

Journal: Nature Communications

PubMed ID: 40897699

Doi: 10.1038/s41467-025-63479-y.

Ultrastrong Staphylococcus aureus adhesion to human skin: Calcium as a key regulator of noncovalent interactions

Authors: Constance Chantraine, Priscila S F C Gomes, Marion Mathelié-Guinlet, Diego E B Gomes, Zhiyong Zheng, Julianne Clowry, Mary B Turley, Alan D Irvine, Joan A Geoghegan, Rafael C Bernardi, Yves F Dufrêne

Journal: SCIENCE ADVANCES

PubMed ID: 40901964

Doi: 10.1126/sciadv.adu7457

The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses

Authors: Kira Schamoni-Kast, Boris Krichel, Tomislav Damjanović, Fatema-Aqila Said, Thomas Kierspel, Sibel Toker, Charlotte Uetrecht

Journal: Nature Communications

PubMed ID: 40925907

Doi: 10.1038/s41467-025-61554-y.

Products & Services: Gene Services