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GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer

Authors: Jingyi Wu, Peng Qian, Yifeng Han, Chuning Xu, Mao Xia, Ping Zhan, Jiwu Wei, Jie Dong

Journal: Cellular & molecular immunology

PubMed ID: 39910336

Doi: 10.1038/s41423-025-01260-3

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Network pharmacology analysis of Lanatoside C: molecular targets and mechanisms in the treatment of ulcerative colitis

Authors: Wenjing Zhu; Zhengjie Zhang; Xinyuan Wang

Journal: Frontiers in molecular biosciences

PubMed ID: 40191037

Doi: 10.3389/fmolb.2025.1552360

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Authors: Chenkai Li; Darcy Sutherland; S. Austin Hammond; Chen Yang; Figali Taho; Lauren Bergman; Simon Houston; Ren L. Warren; Titus Wong; Linda M. N. Hoang; Caroline E. Cameron; Caren C. Helbing; Inanc Birol

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

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A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade

Authors: Yijian Qiu; Olivia T. Stamatatos; Qingting Hu; Jed de Ruiter Swain; Suzanne Russo; Ava Sann; Ana S. H. Costa; Sara Violante; David L. Spector; Justin R. Cross; Michael J. Lukey

Journal: Nature metabolism

PubMed ID: 39192144

Doi: 10.1038/s42255-024-01104-w

FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

Authors: Ambroise Wonkam, Kevin Esoh, Rachel M Levine, Valentina Josiane Ngo Bitoungui, Khuthala Mnika, Nikitha Nimmagadda, Erin A D Dempsey, Siana Nkya, Raphael Z Sangeda, Victoria Nembaware, Jack Morrice, Fujr Osman, Michael A Beer, Julie Makani, Nicola Mulder, Guillaume Lettre, Martin H Steinberg, Rachel Latanich, James F Casella, Daiana Drehmer, Dan E Arking, Emile R Chimusa, Jonathan S Yen, Gregory A Newby, Stylianos E Antonarakis

Journal: Nature Communications

PubMed ID: 40025045

Doi: 10.1038/s41467-025-57413-5

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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Authors: Liora S Katz, Emira J Visser, Kathrin F Plitzko, Marloes A M Pennings, Peter J Cossar, Isabelle L Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann, Donald K Scott

Journal: Nature Communications

PubMed ID: 40025013

Doi: 10.1038/s41467-025-57241-7

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Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage

Authors: Jiho Nam, Hyunmin Woo, Jihye Yang, Seok Jung Kim, Kwang Pyo Lee, Ji Hoon Yu, Tae Joo Park, Seong-Il Eyun, Siyoung Yang

Journal: Advanced Science

PubMed ID: 40040621

Doi: 10.1002/advs.202404311

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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

Authors: Charles Bou-Nader, Katie A Link, Krishna C Suddala, Jay R Knutson, Jinwei Zhang

Journal: Nature Communications

PubMed ID: 40050622

Doi: 10.1038/s41467-025-57519-w

Products & Services: Peptide Synthesis

Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Authors: Loϊc Binan, Aiping Jiang, Serwah A Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T Manguso, Kathleen B Yates, Ralda Nehme, Brian Cleary, Samouil L Farhi

Journal: Cell

PubMed ID: 40081369

Doi: 10.1016/j.cell.2025.02.012

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