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CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Authors: Feng Li, Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Huy Nguyen, Sirisha Mukkavalli, Roger A Greenberg, Alan D D'Andrea

Journal: Nature Communications

PubMed ID: 39962076

Doi: 10.1038/s41467-025-56834-6

Products & Services: CRISPR Plasmids

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

Authors: Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson,on Jay Lihm, George Payne, Olga Lyudovyk, Luis A Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M Bruno, Siqi Linsey Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yad,av Taha Merghoub, Jedd D Wolchok, Olca Basturk, Mithat Gönen, Andrew S Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M Varghese, Elizabeth Won, Avni Desai, Alice C Wei, Michael I D'Angelica, T Peter Kingham, Kevin C Soares, William R Jarnagin, Jeffrey Drebin, Eileen M O'Reilly, Ira Mellman, Ugur Sahin, Özlem Türeci, Benjamin D Greenbaum, Vinod P Balachandran

Journal: Nature

PubMed ID: 39972124

Doi: 10.1038/s41586-024-08508-4

Products & Services: Peptide Synthesis

Cooperative nutrient scavenging is an evolutionary advantage in cancer

Authors: Gizem Guzelsoy, Setiembre D Elorza, Manon Ros, Logan T Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S Brunner, Ray Pillai, William E Walkowicz, Lydia W S Finley, Maxime Deforet, Thales Papagiannakopoulos, Carlos Carmona-Fontaine

Journal: Nature

PubMed ID: 39972131

Doi: 10.1038/s41586-025-08588-w

Products & Services: Peptide Synthesis

Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota

Authors: Jana Ordon、Elke Logemann、Louis-Philippe Maier、Tak Lee、Eik Dahms、Anniek Oosterwijk、Jose Flores-Uribe、Shingo Miyauchi、Lucas Paoli、Sara Christina Stolze、Hirofumi Nakagami、Georg Felix、Ruben Garrido-Oter、Ka-Wai Ma 和 Paul Schulze-Lefert

Journal: Nat Plants

PubMed ID: 39972185

Doi: 10.1038/s41477-025-01918-w

Products & Services: Peptide Synthesis

Structural basis of ssDNA-guided NADase activation of prokaryotic SPARTA system

Authors: Rong Hu, Chenmin Guo, Xiaotian Liu, Yuanyi Lin, Zixin Yang, Zhixin Li, Ye Yang, Erman Ma, Yiyi Li, Jiyun Chen, Liang Liu

Journal: Nucleic Acids Res

PubMed ID: 39997222

Doi: 10.1093/nar/gkaf110

Products & Services: Gene Synthesis

Reversible ubiquitination conferred by domain shuffling controls paired NLR immune receptor complex homeostasis in plant immunity

Authors: Zhiyi Chen, Jianhua Huang, Jianyu Li, Frank L. H. Menke, Jonathan D. G. Jones & Hailong Guo

Journal: Nature Communications

Doi: 10.1038/s41467-025-57231-9

Products & Services: Protein and Antibody Isolation

ABC transporter activity is affected by the size of lipid nanodiscs

Authors: Annabella Nouel Barreto, Luis G Cuello, Maria E Zoghbi

Journal: FEBS Letters

PubMed ID: 39748569

Doi: 10.1002/1873-3468.15096

Products & Services: Gene Synthesis Custom Vector Construction

Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies

Authors: Yan-Ruide Li, Ying Fang, Siyue Niu, Yichen Zhu, Yuning Chen, Zibai Lyu, Enbo Zhu, Yanxin Tian, Jie Huang, Valerie Rezek, Scott Kitchen, Tzung Hsiai, Jin J Zhou, Pin Wang, Wanxing Chai-Ho, Sunmin Park, Christopher S Seet, Caspian Oliai, Lili Yang

Journal: Nature Communications

PubMed ID: 39893165

Doi: 10.1038/s41467-025-56270-6

Products & Services: Gene Fragments

Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer

Authors: Congcong Chen, Yang Li, Yayun Gu, Qiqi Zhai, Songwei Guo, Jun Xiang, Yuan Xie, Mingxing An, Chenmeijie Li, Na Qin, Yanan Shi, Liu Yang, Jun Zhou, Xianfeng Xu, Ziye Xu, Kai Wang, Meng Zhu, Yue Jiang, Yuanlin He, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Juncheng Dai, Guangfu Jin, Zhibin Hu, Cheng Wang, Hongxia Ma, Hongbing Shen

Journal: Nature Communications

PubMed ID: 39910069

Doi: 10.1038/s41467-025-56725-w

Products & Services: Gene Synthesis

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

Authors: Cheng-Bao Ma, Chen Liu, Young-Jun Park, Jingjing Tang, Jing Chen, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Zheng-Li Shi, Zengqin Deng, David Veesler, Huan Yan

Journal: Cell

PubMed ID: 39922191

Doi: 10.1016/j.cell.2024.12.031

Products & Services: Codon Optimization