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DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Authors: Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu

Journal: Clinical epigenetics

PubMed ID: 40380281

Doi: 10.1186/s13148-025-01874-4

Products & Services: Protein and Antibody Isolation

Mechanistic insights into the stimulation of the histone H3K9 methyltransferase Clr4 by proximal H3K14 ubiquitination

Authors: Yunxiang Du , Maoshen Sun , Zhengqing Li , Xiangwei Wu , Qian Qu , Huasong Ai , Lei Liu

Journal: SCIENCE ADVANCES

PubMed ID: 40446033

Doi: 10.1126/sciadv.adu1864

Products & Services: Gene Synthesis

CRISPR-Based Environmental Biosurveillance Assisted via Artificial Intelligence Design of Guide-RNAs

Authors: Benjamín Durán-Vinet, Jo-Ann L. Stanton, Gert-Jan Jeunen, Ulla von Ammon, Jackson Treece, Xavier Pochon, Anastasija Zaiko, Neil J. Gemmell

Journal: Environmental DNA

Doi: doi.org/10.1002/edn3.70105

Products & Services: Gene Synthesis Plasmid DNA Preparation Custom DNA/RNA Oligos Molecular Biology Reagents

A basigin antibody modulates MCTs to impact tumor metabolism and immunity

Authors: Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao

Journal: Cell Discovery

PubMed ID: 40324980

Doi: 10.1038/s41421-025-00777-1

Products & Services: Protein and Antibody Isolation

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site

Authors: Leslie A Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F Vajdos, Jeffrey W Pelker, Simeon Ramsey, Paul Balbo, Parag V Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W Wright, Jeanne S Chang, John M Curto, Jennifer E Davoren, Susan E Drozda, Kimberly F Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L Lee, Shenping Liu, Frank Lovering, Jennifer A Nicki, John I Trujillo, Fabien Vincent, Mark E Schnute

Journal: Nature Communications

PubMed ID: 40379660

Doi: 10.1038/s41467-025-59919-4

Products & Services: Gene Synthesis

Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation

Authors: Laura A Claessens, Matty Verlaan-de Vries, Nienke Broekman, Martijn S Luijsterburg, Alfred C O Vertegaal

Journal: SCIENCE ADVANCES

PubMed ID: 40367183

Doi: 10.1126/sciadv.adp2643

Products & Services: Gene Synthesis

LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels

Authors: Mihajlo Novakovic, Yaning Han, Nina C Kathe, Yinan Ni, Leonidas Emmanouilidis, Frédéric H-T Allain

Journal: Nature Communications

PubMed ID: 40389460

Doi: 10.1038/s41467-025-59759-2

Products & Services: Custom Vector Construction

Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins

Authors: Justin M Bradley , Zinnia Bugg , Jacob Pullin , Geoffrey R Moore, Dimitri A Svistunenko , Nick E Le Brun

Journal: Nature Communications

PubMed ID: 40393986

Doi: 10.1038/s41467-025-59463-1

Products & Services: Mutagenesis Services

Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes

Authors: Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Denise Bei Lin Teo, Ka-Wai Cheung, Chin Ren Goh, Faris Kairi, Elizabeth Lee, Francesca Lorraine Wei Inng Lim, Michaela Su-Fern Seng, Shui Yen Soh, Michael E Birnbaum, Jongyoon Han

Journal: Nature Communications

PubMed ID: 40404664

Doi: 10.1038/s41467-025-59789-w

Products & Services: Plasmid DNA Preparation

Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces

Authors: Xiaowei Li, Yanyan Wang, Xin Chen, Leon Eisentraut, Chunjun Zhan, Jens Nielsen, Yun Chen

Journal: Nature Communications

PubMed ID: 40379631

Doi: 10.1038/s41467-025-59966-x

Products & Services: Gene Synthesis