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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Authors: Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau

Journal: PLOS Pathogens

PubMed ID: 37018380

Doi: 10.1371/journal.ppat.1011206

Products & Services: Gene Synthesis

Knockdown of the salivary protein gene NlG14 caused displacement of the lateral oviduct secreted components and inhibited ovulation in Nilaparvata lugens

Authors: Haoli Gao, Huihui Zhang, Xiaowei Yuan, Xumin Lin, Jianzheng Zou, Na Yu, Zewen Liu

Journal: PLOS Genetics

PubMed ID: 37011098

Doi: 10.1371/journal.pgen.1010704

Products & Services: Protein and Antibody Isolation

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

Authors: Jonathan D Teo , Oana C Marian , Alanna G Spiteri , Madeline Nicholson , Huitong Song , Jasmine X Y Khor , Holly P McEwen , Anjie Ge , Monokesh K Sen , Laura Piccio , Jessica L Fletcher , Nicholas J C King , Simon S Murray , Jens C Brüning , Anthony S Don

Journal: Glia .

PubMed ID: 36583573

Doi: 10.1002/glia.24329

Products & Services: Recombinant Proteins

A molecular study on recombinant pullulanase type I from Metabacillus indicus.

Authors: Zahraa Z Al-Mamoori , Amira M Embaby , Ahmed Hussein , Hoda E Mahmoud

Journal: AMB Express

PubMed ID: 37119334

Doi: 10.1186/s13568-023-01545-8.

Products & Services: Gene Synthesis

Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Authors: Livija Tu ar; Jure Loboda; Francis Impens; Piotr Sosnowski; Emmy Van Quickelberghe; Robert Vidmar; Hans Demol; Koen Sedeyn; Xavier Saelens; Matej Vizovi ek; Marko Miheli ; Marko Fonovi ; Jaka Horvat; Gregor Kosec; Boris Turk; Kris Gevaert; Du an Turk

Journal: Communications Biology

PubMed ID: 37095140

Doi: 10.1038/s42003-023-04772-8

ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Authors: Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lane

Journal: J Cell Biol

PubMed ID: 37014324

Doi: 10.1083/jcb.201910133

Products & Services: Molecular Biology Reagents

Constitutively activated AMPKα1 protects against skeletal aging in mice by promoting bone-derived IGF-1 secretion

Authors: Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang

Journal: Cell Prolif

PubMed ID: 37042047

Doi: 10.1111/cpr.13476

Products & Services: Protein and Antibody Isolation

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

Authors: Madison S. Strine; Wesley L. Cai; Jin Wei; Mia Madel Alfajaro; Renata B. Filler; Scott B. Biering; Sylvia Sarnik; Ryan D. Chow; Ajinkya Patil; Kasey S. Cervantes; Clayton K. Collings; Peter C. DeWeirdt; Ruth E. Hanna; Kevin Schofield; Christopher Hulme; Silvana Konermann; John G. Doench; Patrick D. Hsu; Cigall Kadoch; Qin Yan; Craig B. Wilen

Journal: PLoS biology

PubMed ID: 37310920

Doi: 10.1371/journal.pbio.3002097

Multifunctional activity-based chemical probes for sirtuins

Authors: Chiranjeev Sharma, Dickson Donu, Alyson M Curry, Elizabeth Barton, Yana Cen

Journal: RSC Adv

PubMed ID: 37063743

Doi: 10.1039/d3ra02133e

Products & Services: Protein and Antibody Isolation

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

Authors: Iris D Zelnik, Beatriz Mestre, Jonathan J Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J Fleishman, Anthony H Futerman

Journal: Nat Commun