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Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Authors: Benedikt Goretzki, Christoph Wiedemann, Brett A McCray, Stefan L Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K Donohue, Cy M Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J Sumner, Gerhard Hummer, Ute A Hellmich

Journal: Nat Commun

PubMed ID: 37443299

Doi: 10.1038/s41467-023-39808-4

Products & Services: Plasmid DNA Preparation

Absolute Quantification of Photoreceptor Outer Segment Proteins

Authors: Nikolai P Skiba, Tylor R Lewis, William J Spencer, Carson M Castillo, Andrej Shevchenko, Vadim Y Arshavsky

Journal: J Proteome Res

PubMed ID: 37493966

Doi: 10.1021/acs.jproteome.3c00267

Products & Services: Peptide Synthesis

Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease

Authors: Yingying Jin, Matthew A Downey, Ambuj Singh, Steven K Buratto, Michael T Bowers

Journal: ACS Chem Neurosci

PubMed ID: 37442126

Doi: 10.1021/acschemneuro.3c00266

Products & Services: Protein and Antibody Isolation

TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma

Authors: Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang

Journal: Int J Mol Sci

PubMed ID: 37511490

Doi: 10.3390/ijms241411733

Products & Services: Peptide Synthesis

Structural basis of CXC chemokine receptor 1 ligand binding and activation

Authors: Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R H Tame, Asuka Inoue, Sam-Yong Park

Journal: Nat Commun

PubMed ID: 37433790

Doi: 10.1038/s41467-023-39799-2

Products & Services: Gene Synthesis

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang

Journal: Cell Death Dis

PubMed ID: 37500626

Doi: 10.1038/s41419-023-05958-y

Products & Services: Catalog Peptides

Class I histone deacetylase complex: Structure and functional correlates

Authors: Xiao Wang, Yannan Wang, Simiao Liu, Yi Zhang, Ke Xu, Liting Ji, Roger D Kornberg, Heqiao Zhang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 37459529

Doi: 10.1073/pnas.2307598120

Products & Services: Gene Synthesis Custom Vector Construction

Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

Authors: Peter J. Halfmann; Kathryn Loeffler; Augustine Duffy; Makoto Kuroda; Jie E. Yang; Elizabeth R. Wright; Yoshihiro Kawaoka; Ravi S. Kane

Journal: Nature Communications

PubMed ID: 38346966

Doi: 10.1038/s41467-024-45495-6

Products & Services: PCR Cloning and Subcloning

Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites

Authors: Tana R Gazdik, Jacob J Crow, Tyler Lawton, Chloe J Munroe, Hannah Theriault, Travis M Wood, Allan R Albig

Journal: Res Sq

PubMed ID: 37546896

Doi: 10.21203/rs.3.rs-3147210/v1

Products & Services: Protein and Antibody Isolation

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet

Journal: Commun Biol

PubMed ID: 37430142

Doi: 10.1038/s42003-023-05088-3

Products & Services: Peptide Synthesis Peptide Synthesis