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Human monoclonal antibodies targeting A35 protect from death caused by mpox

Authors: Raianna F. Fantin, Meng Yuan, Seok-Chan Park, Bailey Bozarth, Hallie Cohn, Maxinne Ignacio, Patricia Earl, Alesandro Civljak, Gabriel Laghlali, Ding Zhang, Xueyong Zhu, Jameson Crandell, Valter Monteiro, Jordan J. Clark, Catherine Cotter, Martin Burkhardt, Gagandeep Singh, Prajakta Warang, Juan García-Bernalt Diego, Komal Srivastava, Luz A. Lugo, Lauren Pischel, PVI study group, Inci Yildirim, Saad B. Omer, Daniel da Silva, Florian Krammer, Goran Bajic, Viviana Simon, Michael Schotsaert, Carolina Lucas, Ian A. Wilson, Bernard Moss, Camila H. Coelho

Journal: Cell

Doi: 10.1016/j.cell.2025.08.004

Products & Services: DNA Sequencing

Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping

Authors: Nunziata Maio, Umberto Terranova, Yan Li, J Martin Bollinger Jr, Carsten Krebs, Tracey A Rouault

Journal: Nature Communications

PubMed ID: 40817372

Doi: 10.1038/s41467-025-62832-5.

Products & Services: Polyclonal Antibody Services

A Dapl1+ subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors

Authors: Adam C Lynch, Kaito A Hioki, Xueting Liang, Iris Thesmar, Julia Cernjul, Xinjian Doris He, Jesse Mager, Wei Cui, Dominique Alfandari, Elena L Pobezinskaya, Leonid A Pobezinsky

Journal: SCIENCE ADVANCES

PubMed ID: 40845112

Doi: 10.1126/sciadv.adx5687

Products & Services: Custom Vector Construction

Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells

Authors: George D Lampe, Ashley R Liang, Dennis J Zhang, Israel S Fernández, Samuel H Sternberg

Journal: Nature Communications

PubMed ID: 40849322

Doi: 10.1038/s41467-025-63164-0.

Products & Services: Bacterial Expression

O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism

Authors: Hong Dong, Chenxi Liang, Junjie Zhang, Weidong Wu, Nitesh Kumar, Zihao Liu, Yajun Sun, Zhiwei Liao, Xiaolin Cheng, Yanbao Yu, Yong Zhang, Michael J Holtzman, Jianrong Li, Kymberly M Gowdy, Paul G Thomas, Jovica D Badjic, Anjun Ma, Qin Ma, Jacob S Yount, Shan-Lu Liu, Haitao Wen

Journal: Nature Communications

PubMed ID: 40830102

Doi: 10.1038/s41467-025-63085-y.

Products & Services: Catalog Peptides

Internal ribosome entry sites enhance translation in trans in antisense non-coding SINEUP and circular RNAs

Authors: Sabrina D'Agostino, Abraham Tettey-Matey, Massimiliano Volpe, Bianca Pierattini, Mattia D'Agostino, Denisa Smělá, Federico Ansaloni, Laura Broglia, Pierre Lau, Omar Peruzzo, Clarissa Braccia, Andrea Armirotti, Margherita Scarpato, Devid Damiani, Gloria Ros, Valerio Di Carlo, Federica Maniscalco, Elias Bechara, Gian Gaetano Tartaglia, Piero Carninci, Claudio Santoro, Francesca Persichetti, Luca Pandolfini, Angelita Simonetti, Stefano Espinoza, Silvia Zucchelli, Remo Sanges, Carlotta Bon, Stefano Gustincich

Journal: Nucleic Acids Research

PubMed ID: 40823812

Doi: 10.1093/nar/gkaf788

Products & Services: Custom Vector Construction

The NSP5, ORF6 and NSP13 of SARS-CoV-2 Cooperate to Modulate Inflammatory Cell Death Activation

Authors: Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng

Journal: Advanced Science

PubMed ID: 40810650

Doi: 10.1002/advs.202503977

Products & Services: Protein and Antibody Isolation

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM

Authors: James A Ferguson, Sai Sundar Rajan Raghavan, Garazi Peña Alzua, Disha Bhavsar, Jiachen Huang, Alesandra J Rodriguez, Jonathan L Torres, Maria Bottermann, Julianna Han, Florian Krammer, Facundo D Batista, Andrew B Ward

Journal: SCIENCE ADVANCES

PubMed ID: 40815640

Doi: 10.1126/sciadv.adv8257

Products & Services: Recombinant Antibody Expression

Structural basis for small molecule binding to the SARS-CoV-2 nsp10-nsp14 ExoN complex

Authors: Frank Kozielski, Suzanne Zoë Fisher, Shumeng Ma, Fatma Al Busaidi, Ewa Krupinska, Maria Nyblom, Céleste Sele, Heather McDuffie Sullivan, Tobias Krojer, Wolfgang Knecht

Journal: Nucleic Acids Research

PubMed ID: 40794865

Doi: 10.1093/nar/gkaf753

Products & Services: Codon Optimization

Expanding the cytokine receptor alphabet reprograms T cells into diverse states

Authors: Yang Zhao, Masato Ogishi, Aastha Pal, Leon L. Su, Pingdong Tao, Hua Jiang, Grayson E. Rodriguez, Xiaojing Chen, Qinli Sun, Lea Wenting Rysavy, Sam Limsuwannarot, Deepa Waghray, Anusha Kalbasi, K. Christopher Garcia

Journal: Nature

PubMed ID: 40804519

Doi: 10.1038/s41586-025-09393-1.

Products & Services: Peptide Synthesis