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A molecular dynamics-guided mutagenesis identifies two aspartic acid residues involved in the pH-dependent activity of OG-OXIDASE 1

Authors: Anna Scortica, Matteo Capone, Daniele Narzi, Mario Frezzini, Valentina Scafati, Moira Giovannoni, Francesco Angelucci, Leonardo Guidoni, Benedetta Mattei, Manuel Benedetti

Journal: Plant Physiol Biochem

PubMed ID: 34800821

Doi: 10.1016/j.plaphy.2021.11.011

Products & Services: Gene Synthesis

The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase signaling and activating the nuclear factor erythroid-related factor 2 signaling pathway

Authors: Fangxiang Mu, Yuqing Wang, Hong Wu, Qingxia You, Daimin Zhang

Journal: Bioengineered

PubMed ID: 34783297

Doi: 10.1080/21655979.2021.2005932

Products & Services: Plasmid DNA Preparation

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Authors: Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L Udaskin, Ahmet Mentes, Richard Huang, Betty P K Poon, Wenguang He, Ivette Valencia-Sama, Claire M Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S Irwin, Jeffrey E Lee, Ming-Sound Tsao, Brian Raught, Christopher B Marshall, Michael Ohh, Mitsuhiko Ikura

Journal: Nat Commun

PubMed ID: 34725361

Doi: 10.1038/s41467-021-26526-y

Products & Services: Bacterial Expression

Tasquinimod efficacy and S100A9 expression in glucose-treated HREC cells

Authors: Ji Jin, Ji Zhang, Shuyang Bu

Journal: Int Ophthalmol

PubMed ID: 34796432

Doi: 10.1007/s10792-021-02038-y

Products & Services: Gene Synthesis

DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation

Authors: Ronghui Lou, Weizhen Liu, Rongjie Li, Shanshan Li, Xuming He, Wenqing Shui

Journal: Nat Commun

PubMed ID: 34795227

Doi: 10.1038/s41467-021-26979-1

Products & Services: Peptide Synthesis

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

Authors: Ehab Al-Moubarak, Holly A Shiels, Yihong Zhang, Chunyun Du, Oliver Hanington, Stephen C Harmer, Christopher E Dempsey, Jules C Hancox

Journal: Cell Mol Life Sci

PubMed ID: 34727194

Doi: 10.1007/s00018-021-03967-8

Products & Services: Gene Synthesis

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Authors: Wanqiu Li, Linlin Wang, Bradley M. Wierbowski, Mo Lu, Feitong Dong, Wenchen Liu, Sisi Li, Peiyi Wang, Adrian Salic, Xin Gong

Journal: Nature Communications

Doi: doi.org/10.1038/s41467-021-27257-w

Products & Services: Protein and Antibody Isolation

ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments

Authors: Bjarte Aarmo Lund, Bjørn Olav Brandsdal

Journal: Molecules

Doi: 10.3390/molecules26237155

Products & Services: Gene Synthesis

A Novel Type of PD-L1 Inhibitor rU1 snRNPA From Human-Derived Protein Scaffolds Library

Authors: Chuang Ma, Sennan Qiao, Zhiyi Liu, Liang Shan, Chongyang Liang, Meiling Fan, Fei Sun

Journal: Front Oncol.

PubMed ID: 34912719

Doi: doi.org/10.3389/fonc.2021.781046

Products & Services: Recombinant Proteins

SARS-CoV-2 exposure in wild white-tailed deer ()

Authors: Jeffrey C Chandler, Sarah N Bevins, Jeremy W Ellis, Timothy J Linder, Rachel M Tell, Melinda Jenkins-Moore, J Jeffrey Root, Julianna B Lenoch, Suelee Robbe-Austerman, Thomas J DeLiberto, Thomas Gidlewski, Mia Kim Torchetti, Susan A Shriner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34732584

Doi: 10.1073/pnas.2114828118

Products & Services: Serology SARS-Cov-2 detection kits