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BAG3 induces α-SMA expression in human fibroblasts and its over-expression correlates with poorer survival in fibrotic cancer patients

Authors: Margot De Marco, Nicoletta Del Papa, Francesca Reppucci, Vittoria Iorio, Anna Basile, Antonia Falco, Roberta Iaccarino, Sergio Brongo, Francesco De Caro, Mario Capunzo, Maria Caterina Turco, Alessandra Rosati, Liberato Marzullo

Journal: J Cell Biochem

PubMed ID: 34741483

Doi: 10.1002/jcb.30171

Products & Services: Gene Fragments

An early wave of macrophage infiltration intertwined with antigen specific proinflammatory T-cells and browning of adipose tissue characterizes the onset of orbital inflammation in a mouse model of Graves' orbitopathy

Authors: Svenja Philipp, Mareike Horstmann, Matthias Hose, Anke Daser, Gina-Eva Görtz, Christoph Jesenek, Ulrich Flögel, Wiebke Hansen, Nikolaos Bechrakis, J Paul S Banga, Anja Eckstein, Utta Berchner-Pfannschmidt

Journal: Thyroid

PubMed ID: 34779257

Doi: 10.1089/thy.2021.0464

Products & Services: Gene Synthesis

A periplasmic cupredoxin with a green CuT15 center is involved in bacterial copper tolerance

Authors: Anne Durand, Mélanie Fouesnard, Marie-Line Bourbon, Anne-Soisig Steunou, Elisabeth Lojou, Pierre Dorlet, Soufian Ouchane

Journal: Metallomics

PubMed ID: 34791351

Doi: 10.1093/mtomcs/mfab067

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miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia

Authors: Enbo Wang, Yunyan Zhang, Rongmei Ding, Xiaohua Wang, Shumin Zhang, Xinghua Li

Journal: Mol Med Rep

PubMed ID: 34821370

Doi: 10.3892/mmr.2021.12543

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Incomplete radiofrequency ablation induced chemoresistance by up-regulating heat shock protein 70 in hepatocellular carcinoma

Authors: Fuan Wang, Chuan Xu, Guiling Li, Penghua Lv, Jianping Gu

Journal: Exp Cell Res

PubMed ID: 34801560

Doi: 10.1016/j.yexcr.2021.112910

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Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor

Authors: Varsha Ashok Walvekar, Karthik Ramesh, Chacko Jobichen, Muthu Kannan, J Sivaraman, R Manjunatha Kini, Yu Keung Mok

Journal: Protein Sci

PubMed ID: 34800067

Doi: 10.1002/pro.4245

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Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Authors: Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A L Bennett, Angela M Crawley, Patrick M Giguère, Curtis Cooper, Marc-André Langlois

Journal: EBioMedicine

PubMed ID: 34861490

Doi: 10.1016/j.ebiom.2021.103700

Products & Services: Codon Optimization

The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits and Mammalian Thioredoxin Reductases by Targeting Different Residues

Authors: Ricardo Colon, Michelle Wheater, Emily J Joyce, Emma J Ste Marie, Robert J Hondal, Kathleen S Rein

Journal: J Nat Prod

PubMed ID: 34752085

Doi: 10.1021/acs.jnatprod.1c00795

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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Authors: Sophie M-C Gobeil, Benjamin G Bobay, Praveen R Juvvadi, D Christopher Cole, Joseph Heitman, William J Steinbach, Ronald A Venters, Leonard D Spicer

Journal: MBio

PubMed ID: 34809463

Doi: 10.1128/mBio.03000-21

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Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation

Authors: Anne Schreiber, Ben C Collins, Colin Davis, Radoslav I Enchev, Angie Sedra, Rocco D'Antuono, Ruedi Aebersold, Matthias Peter

Journal: Mol Cell

PubMed ID: 34798055

Doi: 10.1016/j.molcel.2021.10.024

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