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Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway

Authors: Kelan Yuan, Jiao Zheng, Xiao Shen, Yaying Wu, Yu Han, Xiuming Jin, Xiaodan Huang

Journal: Int Immunopharmacol

PubMed ID: 34906854

Doi: 10.1016/j.intimp.2021.108426

Products & Services: Protein and Antibody Isolation

Impact of Molecular Modifications on the Immunogenicity and Efficacy of Recombinant Raccoon Poxvirus-Vectored Rabies Vaccine Candidates in Mice

Authors: Carly M Malavé, Jaime Lopera-Madrid, Lex G Medina-Magües, Tonie E Rocke, Jorge E Osorio

Journal: Vaccines (Basel)

PubMed ID: 34960182

Doi: 10.3390/vaccines9121436

Products & Services: Plasmid DNA Preparation

Synthesis of Human Bone Morphogenetic Protein-2 (hBMP-2) in Periplasmic Space: Its Characterization and Preclinical Testing

Authors: João E Oliveira, Miriam F Suzuki, Renata Damiani, Eliana R Lima, Kleicy C Amaral, Anderson M S Santos, Geraldo S Magalhães, Leonardo P Faverani, Luís A V D Pereira, Paolo Bartolini

Journal: Cells

PubMed ID: 34944033

Doi: 10.3390/cells10123525

Products & Services: Protein and Antibody Isolation

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants

Authors: Sisi Shan, Chee Keng Mok, Shuyuan Zhang, Jun Lan, Jizhou Li, Ziqing Yang, Ruoke Wang, Lin Cheng, Mengqi Fang, Zhen Qin Aw, Jinfang Yu, Qi Zhang, Xuanling Shi, Tong Zhang, Zheng Zhang, Jianbin Wang, Xinquan Wang, Justin Jang Hann Chu, Linqi Zhang

Journal: Front Immunol

PubMed ID: 34966387

Doi: 10.3389/fimmu.2021.766821

Products & Services: Mammalian Expression

Engineering CAR-T cells to activate small-molecule drugs in situ

Authors: Thomas J Gardner, J Peter Lee, Christopher M Bourne, Dinali Wijewarnasuriya, Nihar Kinarivala, Keifer G Kurtz, Broderick C Corless, Megan M Dacek, Aaron Y Chang, George Mo, Kha M Nguyen, Renier J Brentjens, Derek S Tan, David A Scheinberg

Journal: Nat Chem Biol

PubMed ID: 34969970

Doi: 10.1038/s41589-021-00932-1

Products & Services: Protein and Antibody Isolation

Design of Mimetic Antibodies Targeting the SARS-CoV-2 Spike Glycoprotein Based on the GB1 Domain: A Molecular Simulation and Experimental Study

Authors: Anderson A. E Santo; Aline Reis; Anderson A. Pinheiro; Paulo I. da Costa; Gustavo T. Feliciano

Journal: Biochemistry

PubMed ID: 40096593

Doi: 10.1021/acs.biochem.4c00671

Structural insights into Ubr1-mediated N-degron polyubiquitination

Authors: Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu, Lei Liu, Minglei Zhao

Journal: Nature.

PubMed ID: 34789879

Doi: 10.1038/s41586-021-04097-8

Products & Services: Gene Synthesis

EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations

Authors: Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Mol Cancer

PubMed ID: 34856977

Doi: 10.1186/s12943-021-01456-x

Products & Services: Synthetic Guide RNA Plasmid DNA Preparation

Prevotella copri ameliorates cholestasis and liver fibrosis in primary sclerosing cholangitis by enhancing the FXR signalling pathway

Authors: Baorong Jiang, Gehui Yuan, Jialin Wu, Qian Wu, Lei Li, Ping Jiang

Journal: Biochim Biophys Acta Mol Basis Dis

Doi: 10.1016/j.bbadis.2021.166320

Products & Services: Custom DNA/RNA Oligos

Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes

Authors: Ziyi Guo, Xunjin Zeng, Yu Zheng

Journal: Bioengineered