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Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

Authors: Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S Lipshutz

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35505663

Doi: 10.1016/j.omtm.2022.03.015

Products & Services: Custom Vector Construction

Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules

Authors: Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase

Journal: Sci Adv

PubMed ID: 35245125

Doi: 10.1126/sciadv.abj9867

Products & Services: Peptide Synthesis

The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles

Authors: Nathane C Mebus-Antunes, Wellington S Ferreira, Glauce M Barbosa, Thais C Neves-Martins, Gilberto Weissmuller, Fabio C L Almeida, Andrea T Da Poian

Journal: PLoS ONE

PubMed ID: 35231063

Doi: 10.1371/journal.pone.0264643

Products & Services: Protein and Antibody Isolation

CRISPR/Cas9-Based Mutagenesis of Histone H31 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Authors: Zoltán Mészár, Éva Kókai, Rita Varga, László Ducza, Tamás Papp, Monika Béresová, Marianna Nagy, Péter Szücs, Angelika Varga

Journal: Int J Mol Sci

PubMed ID: 35328599

Doi: 10.3390/ijms23063178

Products & Services: Custom Vector Construction

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients

Authors: Mepur H Ravindranath, Narendranath M Ravindranath, Fatiha El Hilali, Senthamil R Selvan, Edward J Filippone

Journal: Antibodies (Basel)

PubMed ID: 35323192

Doi: 10.3390/antib11010018

Products & Services: Protein and Antibody Isolation

Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Authors: Kelly J Culhane, Tejas M Gupte, Indrani Madhugiri, Chetan J Gadgil, Sivaraj Sivaramakrishnan

Journal: Nat Commun

PubMed ID: 35260563

Doi: 10.1038/s41467-022-28789-5

Products & Services: Catalog Peptides

MiR-183-5p overexpression in bone mesenchymal stem cell-derived exosomes protects against myocardial ischemia/reperfusion injury by targeting FOXO1

Authors: Shuai Mao, Jing Zhao, Zhao-Juan Zhang, Qin Zhao

Journal: Immunobiology

PubMed ID: 35314383

Doi: 10.1016/j.imbio.2022.152204

Products & Services: Recombinant Proteins

Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

Authors: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R Otten, Ethan C Settembre, Yingxia Wen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35345593

Doi: 10.1016/j.omtm.2022.03.013

Products & Services: Mammalian Expression

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Authors: Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii

Journal: Protein Expr Purif

PubMed ID: 35307559

Doi: 10.1016/j.pep.2022.106089

Products & Services: PCR Cloning and Subcloning

METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma

Authors: Lili Zhang, Xiaofang Luo, Sen Qiao

Journal: Br J Cancer

PubMed ID: 35249103

Doi: 10.1038/s41416-022-01757-y

Products & Services: Gene Synthesis