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Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Authors: Kelly J Culhane, Tejas M Gupte, Indrani Madhugiri, Chetan J Gadgil, Sivaraj Sivaramakrishnan

Journal: Nat Commun

PubMed ID: 35260563

Doi: 10.1038/s41467-022-28789-5

Products & Services: Catalog Peptides

MiR-183-5p overexpression in bone mesenchymal stem cell-derived exosomes protects against myocardial ischemia/reperfusion injury by targeting FOXO1

Authors: Shuai Mao, Jing Zhao, Zhao-Juan Zhang, Qin Zhao

Journal: Immunobiology

PubMed ID: 35314383

Doi: 10.1016/j.imbio.2022.152204

Products & Services: Recombinant Proteins

Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

Authors: Giuseppe Palladino, Cheng Chang, Changkeun Lee, Nedzad Music, Ivna De Souza, Jonathan Nolasco, Samuel Amoah, Pirada Suphaphiphat, Gillis R Otten, Ethan C Settembre, Yingxia Wen

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35345593

Doi: 10.1016/j.omtm.2022.03.013

Products & Services: Mammalian Expression

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Authors: Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii

Journal: Protein Expr Purif

PubMed ID: 35307559

Doi: 10.1016/j.pep.2022.106089

Products & Services: PCR Cloning and Subcloning

METTL14-mediated N6-methyladenosine modification of Pten mRNA inhibits tumour progression in clear-cell renal cell carcinoma

Authors: Lili Zhang, Xiaofang Luo, Sen Qiao

Journal: Br J Cancer

PubMed ID: 35249103

Doi: 10.1038/s41416-022-01757-y

Products & Services: Gene Synthesis

Inactivated SARS-CoV-2 vaccine in primary Sjögren's syndrome: humoral response, safety, and effects on disease activity

Authors: Sandra Gofinet Pasoto, Ari Stiel Radu Halpern, Lissiane Karine Noronha Guedes, Ana Cristina Medeiros Ribeiro, Emily Neves Figueiredo Yuki, Carla Gonçalves Schahin Saad, Clovis Artur Almeida da Silva, Léonard de Vinci Kanda Kupa, Lorena Elizabeth Betancourt Villamarín, Victor Adriano de Oliveira Martins, Carolina Campagnoli Machado Freire Martins, Giordano Bruno Henriques Deveza, Elaine Pires Leon, Cleonice Bueno, Tatiana Nascimento Pedrosa, Roseli Eliana Beseggio Santos, Renata Soares, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Clin Rheumatol

PubMed ID: 35306594

Doi: 10.1007/s10067-022-06134-x

Products & Services: Catalog Antibodies

Insight into Cellular Uptake and Transcytosis of Peptide Nanoparticles in Cells and Isolated Midgut

Authors: Erin McGraw, Jonathan D Roberts, Nitish Kunte, Matthew Westerfield, Xavier Streety, David Held, L Adriana Avila

Journal: ACS Omega

PubMed ID: 35415340

Doi: 10.1021/acsomega.1c06638

Products & Services: Molecular Biology Tools

Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production

Authors: Jin Zhao, Jiaoshan Chen, Congcong Wang, Yajie Liu, Minchao Li, Yanjun Li, Ruiting Li, Zirong Han, Junjian Wang, Ling Chen, Yuelong Shu, Genhong Cheng, Caijun Sun

Journal: PLoS Pathog

PubMed ID: 35235615

Doi: 10.1371/journal.ppat.1010366

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Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway

Authors: Yang Bai, Jiaqi Chen, Weijian Hu, Lei Wang, Yulian Wu, Shi'an Yu

Journal: Front Pharmacol

PubMed ID: 35401195

Doi: 10.3389/fphar.2022.847905

Products & Services: Protein Electrophoresis and Western

Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

Authors: Lili Yang, Zhengjun Li, Yao Chen, Feiyan Chen, Haopeng Sun, Min Zhao, Yanqi Chen, Yali Wang, Wenlin Li, Li Zeng, Yaoyao Bian

Journal: Oxid Med Cell Longev

PubMed ID: 35308169

Doi: 10.1155/2022/9226022

Products & Services: Mutant Libraries