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Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Authors: Yuqiu Wang, Chen Yang, Hanyang Hu, Chen Chen, Mengdi Yan, Feixiang Ling, Kathy Cheng Wang, Xintao Wang, Zhe Deng, Xinyue Zhou, Feixu Zhang, Sen Lin, Zengmin Du, Kai Zhao, Xiao Xiao

Journal: Mol Ther Nucleic Acids

PubMed ID: 35474733

Doi: 10.1016/j.omtn.2022.03.017

Products & Services: Custom DNA/RNA Oligos

Theileria equi RAP-1a and RAP-1b proteins contain immunoreactive epitopes and are suitable candidates for vaccine and diagnostics development

Authors: Cynthia K Onzere, Lindsay M Fry, Richard P Bishop, Marta Da Silva, Sally A Madsen-Bouterse, Reginaldo G Bastos, Donald P Knowles, Carlos E Suarez

Journal: Int J Parasitol

PubMed ID: 35318949

Doi: 10.1016/j.ijpara.2022.01.004

Products & Services: Recombinant Antibody Expression

Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor

Authors: Haozhou Tan, Chunlong Ma, Jun Wang

Journal: Res Sq

PubMed ID: 35378761

Doi: 10.21203/rs.3.rs-1490282/v1

Products & Services: Codon Optimization

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Authors: Eva Mittler, Anna Z Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Byström, Laura C Polanco, Cecilia M O'Brien, Megan M Slough, Dafna M Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R Bakken, James C Geoghegan, Rohit K Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G Ulrich, Zachary A Bornholdt, Clas Ahlm, Felix A Rey, John M Dye, Steven B Bradfute, Tomas Strandin, Andrew S Herbert, Mattias N E Forsell, Laura M Walker, Kartik Chandran

Journal: Sci Transl Med

PubMed ID: 35294259

Doi: 10.1126/scitranslmed.abl5399

Products & Services: Codon Optimization

Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT

Authors: Bin Li, Minshik Jo, Jianxin Liu, Jiayi Tian, Robert Canfield, Jennifer Bridwell-Rabb

Journal: Commun Biol

PubMed ID: 35347217

Doi: 10.1038/s42003-022-03226-x

Products & Services: Custom Vector Construction

HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens

Authors: David M Koelle, Lichun Dong, Lichen Jing, Kerry J Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M Posavad

Journal: Front Immunol

PubMed ID: 35432373

Doi: 10.3389/fimmu.2022.867962

Products & Services: ORF cDNA Clones/MolecularCloud

Accurate positioning of functional residues with robotics-inspired computational protein design

Authors: Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A Pache, Lin Liu, Shane O Conchúir, Jeliazko R Jeliazkov, Jeffrey J Gray, Michael C Thompson, James S Fraser, Tanja Kortemme

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35254891

Doi: 10.1073/pnas.2115480119

Products & Services: Custom Vector Construction

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir41/51 Inward Rectifier Potassium Channels

Authors: Samantha J McClenahan, Caitlin N Kent, Sujay V Kharade, Elena Isaeva, Jade C Williams, Changho Han, Andrew Terker, Robert Gresham, Roman M Lazarenko, Emily L Days, Ian M Romaine, Joshua A Bauer, Olivier Boutaud, Gary A Sulikowski, Raymond Harris, C David Weaver, Alexander Staruschenko, Craig W Lindsley, Jerod S Denton

Journal: Mol Pharmacol

PubMed ID: 35246480

Doi: 10.1124/molpharm.121.000464

Products & Services: Gene Synthesis

Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains

Authors: Eszter E Najbauer, Sheung Chun Ng, Christian Griesinger, Dirk Görlich, Loren B Andreas

Journal: Nat Commun

PubMed ID: 35314668

Doi: 10.1038/s41467-022-28821-8

Products & Services: Gene Fragments

Heat Shock Protein A6 Is Especially Involved in Enterovirus 71 Infection

Authors: Jiaoyan Jia, Ge Liu, Jianfeng Zhong, Ran Yan, Xun Song, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu

Journal: Front Microbiol

PubMed ID: 35308396

Doi: 10.3389/fmicb.2022.865644

Products & Services: Protein Electrophoresis and Western