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PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek's Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates

Authors: Jason S W On, Liuru Su, Hong Shen, Aloysius W R Arokiaraj, João C R Cardoso, Guang Li, Billy K C Chow

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35498398

Doi: 10.3389/fendo.2022.850040

Products & Services: Catalog Peptides

A small molecule, CHClNOS, inhibits the function of the type III secretion system in Salmonella Typhimurium

Authors: Rerngwit Boonyom, Sittiruk Roytrakul, Patipat Thinwang

Journal: J Genet Eng Biotechnol

PubMed ID: 35380331

Doi: 10.1186/s43141-022-00336-1

Products & Services: Gene Fragments

Collagen type IV alpha 1 (COL4A1) silence hampers the invasion, migration and epithelial-mesenchymal transition (EMT) of gastric cancer cells through blocking Hedgehog signaling pathway

Authors: Xijuan Cui, Tao Shan, Lina Qiao

Journal: Bioengineered

PubMed ID: 35297303

Doi: 10.1080/21655979.2022.2053799

Products & Services: Protein and Antibody Isolation

Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans

Authors: Rasheduzzaman Chowdhury, Martine I Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J Schofield

Journal: Sci Rep

PubMed ID: 35410347

Doi: 10.1038/s41598-022-10028-y

Products & Services: Custom Vector Construction

LncRNA TSPEAR-AS1 predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma and promotes metastasis via miR-1915-5p

Authors: Yichuan Zhang, Fei Wang, Yu Wang

Journal: Virus Res

PubMed ID: 35477008

Doi: 10.1016/j.virusres.2022.198788

Products & Services: Custom DNA/RNA Oligos

DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation

Authors: Xiaoyi Zhang, Tong An, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Weiqing Tang, Jian Li

Journal: Biochem Biophys Res Commun

PubMed ID: 35533489

Doi: 10.1016/j.bbrc.2022.04.129

Products & Services: Mammalian Expression

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Authors: Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, Magnus Essand

Journal: Nat Biomed Eng

PubMed ID: 35379957

Doi: 10.1038/s41551-022-00875-5

Products & Services: PCR Cloning and Subcloning

Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

Authors: Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran

Journal: Cancer Cell

PubMed ID: 35413272

Doi: 10.1016/j.ccell.2022.03.005

Products & Services: Custom Vector Construction

QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®

Authors: Morteza Jaffar-Aghaei, Farzad Khanipour, Amir Maghsoudi, Rahim Sarvestani, Mahdi Mohammadian, Maryam Maleki, Forugh Havasi, Hossein Rahmani, Amir-Hossein Karagah, Mohammad-Reza Kazemali

Journal: Eur J Pharm Sci

PubMed ID: 35378209

Doi: 10.1016/j.ejps.2022.106171

Products & Services: Gene Synthesis

A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Authors: Yanling Wu, Quanxiao Li, Yu Kong, Zhi Wang, Cheng Lei, Ji Li, Lulu Ding, Chunyu Wang, Yaping Cheng, Yaozhu Wei, Yuanlin Song, Zhenlin Yang, Chao Tu, Yu Ding, Tianlei Ying

Journal: Mol Ther

PubMed ID: 35462042

Doi: 10.1016/j.ymthe.2022.04.013

Products & Services: Mammalian Expression