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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

Authors: Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš

Journal: J Enzyme Inhib Med Chem

PubMed ID: 35144520

Doi: 10.1080/14756366.2021.2024527

Products & Services: Plasmid DNA Preparation

Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2

Authors: Jingjing Wu, Yuan Deng, Xin Zhang, Jingjing Ma, Xinqi Zheng, Yue Chen

Journal: Pharm Biol

PubMed ID: 34962431

Doi: 10.1080/13880209.2021.2017467

Products & Services: Custom DNA/RNA Oligos

A De Novo Missense Variant in TUBG2 in a Child with Global Developmental Delay, Microcephaly, Refractory Epilepsy and Perisylvian Polymicrogyria

Authors: Salini Thulasirajah, Xueqi Wang, Erick Sell, Jorge Dávila, David A Dyment, Kristin D Kernohan

Journal: Genes

PubMed ID: 36672848

Doi: 10.3390/genes14010108

Products & Services: Mutagenesis Services

ADAR1 improved Treg cell function through the miR-21b/Foxp3 axis and inhibits the progression of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Authors: Yanru Zhao, Xiaoyan Zheng, Miaojing Li, Jing Zhao, Xiaoning Wang, Huachao Zhu

Journal: Int Immunopharmacol

PubMed ID: 36577155

Doi: 10.1016/j.intimp.2022.109620

Products & Services: Gene Synthesis

Intranasal bovine β-defensin-5 enhances antituberculosis immunity in a mouse model by a novel protein-based respiratory mucosal vaccine

Authors: Zhengmin Liang, Hao Li, Mengjin Qu, Yiduo Liu, Yuanzhi Wang, Haoran Wang, Yuhui Dong, Yulan Chen, Xin Ge, Xiangmei Zhou

Journal: Virulence

PubMed ID: 35603910

Doi: 10.1080/21505594.2022.2080342

Products & Services: Endotoxin Detection & Removal System

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

Authors: Qihong Yan, Ruitian Hou, Xiaohan Huang, Yanjun Zhang, Ping He, Yudi Zhang, Banghui Liu, Qian Wang, Haiyue Rao, Xianying Chen, Xinwei Zhao, Xuefeng Niu, Jincun Zhao, Xiaoli Xiong, Ling Chen

Journal: Emerg Microbes Infect

PubMed ID: 36288106

Doi: 10.1080/22221751.2022.2140611

Products & Services: Protein and Antibody Isolation Gene Synthesis

Evaluation of immunological responses to third COVID-19 vaccine among people treated with sphingosine receptor-1 modulators and anti-CD20 therapy

Authors: Ilana Katz Sand, Sacha Gnjatic, Florian Krammer, Kevin Tuballes, Juan Manuel Carreño, Sammita Satyanarayan, Susan Filomena, Erin Staker, Johnstone Tcheou, Aaron Miller, Michelle Fabian, Neha Safi, Jamie Nichols, Jasmin Patel, Stephen Krieger, Stephanie Tankou, Sam Horng, Sylvia Klineova, Erin Beck, Miriam Merad, Fred Lublin

Journal: Mult Scler Relat Disord

PubMed ID: 36628884

Doi: 10.1016/j.msard.2022.104486

Products & Services: Molecular Biology Reagents

Upconversion nanoparticle-based optogenetic nanosystem for photodynamic therapy and cascade gene therapy

Authors: Xinyue Song, Fengyan Li, Feng Tian, Linlin Ren, Qi Wang, Chengfang Jiang, Tao Yan, Shusheng Zhang

Journal: Acta Biomater

PubMed ID: 36494007

Doi: 10.1016/j.actbio.2022.12.002

Products & Services: Gene Synthesis

Potential of a novel flagellin epitope as a broad-spectrum vaccine candidate against enteric fever

Authors: Shania Vij, Reena Thakur, Laxmi Kumari, Chander Raman Suri, Praveen Rishi

Journal: Microb Pathog

PubMed ID: 36494021

Doi: 10.1016/j.micpath.2022.105936

Products & Services: Peptide Synthesis

Proteolytic activation of human-specific Olduvai domains by the furin protease

Authors: Ashley Pacheco, Aaron Issaian, Jonathan Davis, Nathan Anderson, Travis Nemkov, Natasia Paukovich, Morkos A Henen, Beat Vögeli, James M Sikela, Kirk Hansen

Journal: Int J Biol Macromol

PubMed ID: 36581038

Doi: 10.1016/j.ijbiomac.2022.12.260

Products & Services: Protein and Antibody Isolation