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页码: 393/5369 每页显示数量

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

Authors: Fr d ric A. Dreyer; Constantin Schneider; Aleksandr Kovaltsuk; Daniel Cutting; Matthew J. Byrne; Daniel A. Nissley; Henry Kenlay; Claire Marks; David Errington; Richard J. Gildea; David Damerell; Pedro Tizei; Wilawan Bunjobpol; John F. Darby; Ieva Drulyte; Daniel L. Hurdiss; Sachin Surade; Newton Wahome; Douglas E.V. Pires; Charlotte M. Deane

Journal: MAbs

PubMed ID: 40458889

Doi: 10.1080/19420862.2025.2511220

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

Journal: MAbs

PubMed ID: 40458889

Doi: 10.1080/19420862.2025.2511220

Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Authors: Peibin Liang; Yanpeng Li; Rui Xu; Kutty Selva Nandakumar; Roma Stawikowska; Gregg B. Fields; Rikard Holmdahl

Journal: Molecular Biomedicine

PubMed ID: 35551534

Doi: 10.1186/s43556-022-00076-1

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens

Authors: David Lund; Roelof Dirk Coertze; Marcos Parras-Molt ; Fanny Berglund; Carl-Fredrik Flach; Anna Johnning; D. G. Joakim Larsson; Erik Kristiansson

Journal: Communications Biology

PubMed ID: 37537271

Doi: 10.1038/s42003-023-05174-6

Chromosome recombination and modification by LoxP-mediated evolution in Vibrio natriegens using CRISPR-associated transposases

Authors: Jiaqi Xu, Yijie Sun, Jianping Wu, Sheng Yang, Lirong Yang

Journal: Biotechnol Bioeng

PubMed ID: 38131162

Doi: 10.1002/bit.28639

Products & Services: Gene Synthesis

SAXS/WAXS data of conformationally flexible ribose binding protein

Authors: Jagrity Choudhury, Kento Yonezawa, Anu Anu, Nobutaka Shimizu, Barnali Chaudhuri

Journal: Data Brief

PubMed ID: 38178847

Doi: 10.1016/j.dib.2023.109932

Products & Services: Molecular Biology Reagents

A naturally occurring HA-stabilizing amino acid (HA1-Y17) in an A(H9N2) low-pathogenic influenza virus contributes to airborne transmission

Authors: Xiangjie Sun, Jessica A Belser, Joanna A Pulit-Penaloza, Nicole Brock, Troy J Kieran, Hui Zeng, Claudia Pappas, Terrence M Tumpey, Taronna R Maines

Journal: MBio

PubMed ID: 38112470

Doi: 10.1128/mbio.02957-23

Products & Services: Recombinant Proteins

Discovery of GPX4 inhibitors through FP-based high-throughput screening

Authors: Yu Cao, Bin Wu, Ying Xu, Mingchen Wang, Xinyu Wu, Xiaochen Liang, Jin Lin, Zhihai Li, Hua Lin, Cheng Luo, Shijie Chen

Journal: Eur J Med Chem

PubMed ID: 38145603

Doi: 10.1016/j.ejmech.2023.116044

Products & Services: Catalog Peptides

HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling

Authors: Felipe Paredes, Mario Navarro-Marquez, Clara Quiroga, Danica Jiménez-Gallegos, Samantha M Yeligar, Valentina Parra, Marioly Müller, Mario Chiong, Andrew F G Quest, Alejandra San Martin, Sergio Lavandero

Journal: Free Radic Biol Med

PubMed ID: 38043868

Doi: 10.1016/j.freeradbiomed.2023.11.022

Products & Services: Protein and Antibody Isolation

Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Authors: Jeladhara Sobhanan, Kenji Ono, Takuya Okamoto, Makoto Sawada, Paul S Weiss, Vasudevanpillai Biju

Journal: Chem Sci

PubMed ID: 38332815

Doi: 10.1039/d3sc03877g

Products & Services: Molecular Biology Reagents