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PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

Authors: Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M McAloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 39964718

Doi: 10.1073/pnas.2420961122

Products & Services: Peptide Synthesis

Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3′ UTR via HuR anchorage

Authors: Xinghuan Ma , Sujia Liu , Bangda Fan , Danni Jin , Lei Miao , Lin Liu , Shubo Du , Jiaqi Lin

Journal: Mol Ther Nucleic Acids

PubMed ID: 40125272

Doi: doi.org/10.1016/j.omtn.2025.102485

Products & Services: Gene Synthesis

Controllable intein splicing and N-terminal cleavage at mesophilic temperatures

Authors: Taylor A McNeal, Joel Weinberger, Geraldy L S Liman, Tia M Ariagno, David W Wood, Thomas J Santangelo, Christopher W Lennon

Journal: Front Bioeng Biotechnol

PubMed ID: 39991137

Doi: 10.3389/fbioe.2025.1543573

Products & Services: Gene Synthesis Mutagenesis Services

Structural and mechanistic insights into the activation of a short prokaryotic argonaute system from archaeon Sulfolobus islandicus

Authors: Zhikang Dai, Yu Chen, Zeyuan Guan, Xueting Chen, Keyi Tan, Kaiyue Yang, Xuhui Yan, Yidong Liu, Zhou Gong, Wenyuan Han, Tingting Zou

Journal: Nucleic Acids Res

PubMed ID: 39898546

Doi: 10.1093/nar/gkaf059

Products & Services: Gene Synthesis

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

Authors: Sergio M Quiñones-Parra, Stephanie Gras, Thi H O Nguyen, Carine Farenc, Christopher Szeto, Louise C Rowntree, Priyanka Chaurasia, Sneha Sant, Adrianus C M Boon, Dhilshan Jayasinghe, Guus F Rimmelzwaan, Jan Petersen, Peter C Doherty, Adam P Uldrich, Dene R Littler, Jamie Rossjohn, Katherine Kedzierska

Journal: Science immunology

PubMed ID: 39919196

Doi: 10.1126/sciimmunol.adn3805

Products & Services: Peptide Synthesis

Structure of the tilapia lake virus nucleoprotein bound to RNA

Authors: Benoît Arragain, Martin Pelosse, Karine Huard, Stephen Cusack

Journal: Nucleic Acids Res

PubMed ID: 39995042

Doi: 10.1093/nar/gkaf112

Products & Services: Codon Optimization

Bacteria encode post-mortem protein catabolism that enables altruistic nutrient recycling

Authors: Savannah E R Gibson, Isabella Frost, Stephen J Hierons, Tessa Moses, Wilson C K Poon, Stuart A West, Martin J Cann

Journal: Nature Communications

PubMed ID: 39948360

Doi: 10.1038/s41467-025-56761-6

Products & Services: Gene Synthesis

Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential

Authors: Oscar Florez-Vargas, Michelle Ho, Maxwell H Hogshead, Brenen W Papenberg, Chia-Han Lee, Kaitlin Forsythe, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Kimberly J Billingsley, Mikhail Kolmogorov, Melissa Meredith, Benedict Paten, Raj Chari, Chi Zhang, John S Schneekloth, Mitchell J Machiela, Stephen J Chanock, Shahinaz M Gadalla, Sharon A Savage, Sam M Mbulaiteye, Ludmila Prokunina-Olsson

Journal: Nature Communications

PubMed ID: 39956830

Doi: 10.1038/s41467-025-56947-y

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CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Authors: Feng Li, Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Huy Nguyen, Sirisha Mukkavalli, Roger A Greenberg, Alan D D'Andrea

Journal: Nature Communications

PubMed ID: 39962076

Doi: 10.1038/s41467-025-56834-6

Products & Services: CRISPR Plasmids

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

Authors: Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson,on Jay Lihm, George Payne, Olga Lyudovyk, Luis A Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M Bruno, Siqi Linsey Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yad,av Taha Merghoub, Jedd D Wolchok, Olca Basturk, Mithat Gönen, Andrew S Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M Varghese, Elizabeth Won, Avni Desai, Alice C Wei, Michael I D'Angelica, T Peter Kingham, Kevin C Soares, William R Jarnagin, Jeffrey Drebin, Eileen M O'Reilly, Ira Mellman, Ugur Sahin, Özlem Türeci, Benjamin D Greenbaum, Vinod P Balachandran

Journal: Nature

PubMed ID: 39972124

Doi: 10.1038/s41586-024-08508-4

Products & Services: Peptide Synthesis