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C-mannosyltransferase DPY19L1L-mediated Reissner Fiber formation is critical for zebrafish (Danio rerio) body axis straightening

Authors: Guiyou Tian, Lirong Huang, Zhaopeng Xu, Chen Lu, Wei Yuan, Yulin Wu, Zhipeng Liao, Jia Gao, Qiang Luo, Bo Cheng, Xinjun Liao, Huiqiang Lu

Journal: SCIENCE ADVANCES

PubMed ID: 40344050

Doi: 10.1126/sciadv.adv2032

Products & Services: Gene Synthesis

Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense

Authors: Wen-Hao Han, Feng-Bin Zhang, Shun-Xia Ji, Kai-Lu Liang, Jun-Xia Wang, Xiao-Ping Fan, Shu-Sheng Liu, Xiao-Wei Wang

Journal: SCIENCE ADVANCES

PubMed ID: 40344064

Doi: 10.1126/sciadv.adu5141

Products & Services: Gene Synthesis

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair

Authors: F Li, A S Phadte, M Bhatia, S Barndt, A R Monte Carlo Iii, C-F D Hou, R Yang, S Strock, A Pluciennik

Journal: Nature Communications

PubMed ID: 40368897

Doi: 10.1038/s41467-025-59323-y

Products & Services: Mutagenesis Services

Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP

Authors: Justin M Waldern, Colin Taylor, Catherine A Giannetti, Patrick S Irving, Scott R Allen, Mingyi Zhu, Rolf Backofen, Dave Mathews, Kevin M Weeks, Alain Laederach

Journal: Nucleic Acids Research

PubMed ID: 39713457

Doi: 10.1101/2024.12.13.628372

Products & Services: Gene Synthesis

FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma

Authors: Michal Beffinger, Linda Schellhammer, Betül Taskoparan, Sereina Deplazes, Ulisse Salazar, Nazanin Tatari, Frauke Seehusen, Leopold von Balthazar, Carl Philipp Zinner, Sabine Spath, Tala Shekarian, Marie-Françoise Ritz, Marta McDaid, Pascal Egloff, Iwan Zimmermann, Hideho Okada, E Sally Ward, Jack Rohrer, Markus A Seeger, Thorsten Buch, Gregor Hutter, Johannes Vom Berg

Journal: Nature Communications

PubMed ID: 40404625

Doi: 10.1038/s41467-025-59971-0

Products & Services: Protein Electrophoresis and Western

The ALX4 dimer structure provides insight into how disease alleles impact function

Authors: Brittany Cain , Zhenyu Yuan , Evelyn Thoman, Rhett A Kovall , Brian Gebelein

Journal: Nature Communications

PubMed ID: 40410151

Doi: 10.1038/s41467-025-59728-9

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Authors: Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng

Journal: Advanced Science

PubMed ID: 40349168

Doi: 10.1002/advs.202417733

Products & Services: Protein and Antibody Isolation

HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy

Authors: Shinta Saito, Shingo Kato, Usaki Arai, Atsuki En, Jun Tsunezumi, Taichi Mizushima, Kensuke Tateishi, Noritaka Adachi

Journal: Nature Communications

PubMed ID: 40355434

Doi: 10.1038/s41467-025-59462-2

Products & Services: Gene Synthesis

A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA

Authors: Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F Vogt, Julien Boudet, Brinda C Prasad

Journal: Nature Communications

PubMed ID: 40368883

Doi: 10.1038/s41467-025-59324-x

Products & Services: Gene Synthesis

Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3

Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl

Journal: Nature Communications

PubMed ID: 40360518

Doi: 10.1038/s41467-025-59802-2

Products & Services: Custom Vector Construction