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An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses

Authors: Emily A Aunins, Anthony T Phan, Mohamad-Gabriel Alameh, Garima Dwivedi, Elisa Cruz-Morales, David A Christian, Ying Tam, Molly E Bunkofske, Anabel Zabala Peñafiel, Keenan M O'Dea, Maria Merolle, Colleen Furey, Phillip Scott, Robert H Vonderheide, Scott E Hensley, Ross M Kedl, Drew Weissman, Christopher A Hunter

Journal: Science immunology

PubMed ID: 40478935

Doi: 10.1126/sciimmunol.ads1328

O-GalNAc Glycosylation Activates MBL-Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Authors: Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi-Fai Ng, Jiahua Pan, Wei Xue, Wei-Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu

Journal: Advanced Science

PubMed ID: 40492591

Doi: 10.1002/advs.202504809

Products & Services: Custom Vector Construction

KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis

Authors: Anastasiia Skobelkina, Manon Julien, Sylvain Jeannin, Simona Miron, Tom Egger, Rady Chaaban, Guillaume Bouvignies, Emile Alghoul, Rania Ghouil, Claire Friel, Didier Busso, Juan C Cañas, François-Xavier Theillet, Romain Le Bars, Aura Carreira, Angelos Constantinou, Jihane Basbous, Sophie Zinn-Justin

Journal: Nucleic Acids Research

PubMed ID: 40498077

Doi: 10.1093/nar/gkaf476

Products & Services: Gene Synthesis

ZmSSRP1, transactivated by OPAQUE11, positively regulates starch biosynthesis in maize endosperm

Authors: Long Chen, Chengyun Wu, Quanzhi Li, Ming Du, Yan Li, Beijiu Cheng, Xiaoyu Li, Jiandong Wu

Journal: Plant Biotechnology Journal.

PubMed ID: 40517398

Doi: 10.1111/pbi.70191

Products & Services: Protein and Antibody Isolation

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Authors: Philip Schmiege, Dawid Jaślan, Michael Fine, Nidish Ponath Sadanandan, Alexandra Hatton, Nadia Elghobashi-Meinhardt, Christian Grimm, Xiaochun Li

Journal: Nature Communications

PubMed ID: 40527873

Doi: 10.1038/s41467-025-60710-8

Products & Services: Mutagenesis Services

A four-in-one replicase integrating key enzymatic activities for DNA replication

Authors: Yuxin Zhang , Xueling Lu , Bin Zhu , Fengtao Huang

Journal: Nucleic Acids Research

PubMed ID: 40548937

Doi: 10.1093/nar/gkaf542

Products & Services: Codon Optimization

PAM-free hairpin target binding activates trans-cleavage activity of Cas12a

Authors: Xiaolong Li, Zixuan Zhu, Jiani Wu, Changjiang Li, Zhujun Liu, Jinjin Wang, Pu Li, Zhen Zhang, Yongming Huang, Jiaxin Hong, Tongbo Wu

Journal: Nucleic Acids Research

PubMed ID: 40557869

Doi: 10.1093/nar/gkaf596

Products & Services: CRISPR Plasmids

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non-heading Chinese Cabbage

Authors: Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren

Journal: Advanced Science

PubMed ID: 40549976

Doi: 10.1002/advs.202414954

Mechanistic studies of small molecule ligands selective to RNA single G bulges

Authors: Shalakha Hegde, Sana Akhter, Zhichao Tang, Chang Qi, Chenguang Yu, Anna Lewicka, Yu Liu, Kushal Koirala, Mikhail Reibarkh, Kevin P Battaile, Anne Cooper, Scott Lovell, Erik D Holmstrom, Xiao Wang, Joseph A Piccirilli, Qi Gao, Yinglong Miao, Jingxin Wang

Journal: Nucleic Acids Research

PubMed ID: 40557870

Doi: 10.1093/nar/gkaf559

Sindbis virus is suppressed in the yellow fever mosquito aedes aegypti by Atg6/BECN1 (autophagy-related 6)-mediated activation of autophagy

Authors: Sujit Pujhari, Chan C Heu, Marco Brustolin, Rebecca M Johnson, Donghun Kim, Jason L Rasgon

Journal: Autophagy

PubMed ID: 40574305

Doi: 10.1080/15548627.2025.2523735

Products & Services: Plasmid DNA Preparation