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FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Authors: Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka

Journal: SCIENCE ADVANCES

PubMed ID: 40601736

Doi: 10.1126/sciadv.adu9104

Products & Services: Lentivirus Packaging

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Authors: J Atherton, M S Chegkazi, M Leusciatti, M Di Palma, E Peirano, L S Pozzer, M V A Meli, S Pasqualato, T Foran, G Morra, R A Steiner

Journal: Nature Communications

PubMed ID: 40617823

Doi: 10.1038/s41467-025-61498-3

Products & Services: Mammalian Expression

Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system

Authors: Fanjun Li , Amogh Kumar Baranwal , Sebastian J Maerkl

Journal: Nature Communications

PubMed ID: 40617857

Doi: 10.1038/s41467-025-61671-8

Products & Services: Gene Synthesis

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

Journal: Nature Communications

PubMed ID: 40664627

Doi: 10.1038/s41467-025-61725-x

Products & Services: Custom Vector Construction

Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

Products & Services: Protein and Antibody Isolation

A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek

Journal: Journal of Medicinal Chemistry

PubMed ID: 40650588

Doi: 10.1021/acs.jmedchem.4c03134

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The evolution of eukaryotic linear motifs governing the function of androgen receptor from fish to Homo sapiens

Authors: Antonella Falconieri, Giulia Boarolo, Chiara Boschelle, Giovanni Spagnolli, Caterina Marchioretti, Emanuela Zuccaro, Isabella Palazzolo, Laura Tosatto, Adham Kamaleldeen Omara Hegazy, Jessica Rosati, Kenneth Fischbeck, Manuela Basso, Hans Christoph Liedtke, Ivan Gomez-Mestre, Luisa Dalla Valle, Emiliano Biasini, Pietro Faccioli, Alessandro Grapputo, Maria Pennuto

Journal: Nucleic acids research

PubMed ID: 40682815

Doi: 10.1093/nar/gkaf688

Products & Services: Custom Vector Construction

Engineered Nano-micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization

Authors: Di Wang, Linzhu Zhang, Jihu Nie, Nailin Yang, Shumin Sun, Chunjie Wang, Zifan Pei, Fei Gong, Xingwei Sun, Yong Jin, Liang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 40644662

Doi: 10.1021/jacs.5c06039

β-catenin functions as a molecular adapter for disordered cBAF interactions

Authors: Yuen San Chan, Qinyu Gao, Sarah A Robinson, Wenzhi Wang, Ruzena Filandrova, Lisa-Maria Weinhold, Mario Loeza Cabrera, Miao Zhang, Chandra Shekar R Ambati, Antonio M Lerario, Nagireddy Putluri, Katja Kiseljak-Vassiliades, Margaret E Wierman, Mouhammed Amir Habra, Gary D Hammer, Vaclav Veverka, Katerina Cermakova, H Courtney Hodges

Journal: Molecular Cell

PubMed ID: 40695292

Products & Services: Recombinant Proteins