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页码: 141/5356 每页显示数量

Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system

Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang

Journal: Nat Commun

PubMed ID: 39984501

Doi: 10.1038/s41467-025-57153-6

Products & Services: Gene Synthesis

EXPERT expands prime editing efficiency and range of large fragment edits

Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan

Journal: Nat Commun

PubMed ID: 39939583

Doi: 10.1038/s41467-025-56734-9

Products & Services: Gene Synthesis

Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

Products & Services: Peptide Synthesis

Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

Products & Services: Peptide Synthesis

Expanding Cas12a Activity Control with an RNA G-Quadruplex at the 5′ end of CRISPR RNA

Authors: Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai, Zhenyang Xiang, Chaoxing Liu

Journal: Advanced Science

PubMed ID: 39721016

Doi: 10.1002/advs.202411305

Products & Services: Catalog Gene Editing

The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex

Authors: Lydia P. Tsamouri; Jeffrey C. Hsiao; Daniel A. Bachovchin

Journal: The Journal of Biological Chemistry

PubMed ID: 39615677

Doi: 10.1016/j.jbc.2024.108034

Structural and mechanistic insights into the activation of a short prokaryotic argonaute system from archaeon Sulfolobus islandicus

Authors: Zhikang Dai, Yu Chen, Zeyuan Guan, Xueting Chen, Keyi Tan, Kaiyue Yang, Xuhui Yan, Yidong Liu, Zhou Gong, Wenyuan Han, Tingting Zou

Journal: Nucleic Acids Res

PubMed ID: 39898546

Doi: 10.1093/nar/gkaf059

Products & Services: Gene Synthesis

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

Authors: Sergio M Quiñones-Parra, Stephanie Gras, Thi H O Nguyen, Carine Farenc, Christopher Szeto, Louise C Rowntree, Priyanka Chaurasia, Sneha Sant, Adrianus C M Boon, Dhilshan Jayasinghe, Guus F Rimmelzwaan, Jan Petersen, Peter C Doherty, Adam P Uldrich, Dene R Littler, Jamie Rossjohn, Katherine Kedzierska

Journal: Science immunology

PubMed ID: 39919196

Doi: 10.1126/sciimmunol.adn3805

Products & Services: Peptide Synthesis

Structure of the tilapia lake virus nucleoprotein bound to RNA

Authors: Benoît Arragain, Martin Pelosse, Karine Huard, Stephen Cusack

Journal: Nucleic Acids Res

PubMed ID: 39995042

Doi: 10.1093/nar/gkaf112

Products & Services: Codon Optimization

Bacteria encode post-mortem protein catabolism that enables altruistic nutrient recycling

Authors: Savannah E R Gibson, Isabella Frost, Stephen J Hierons, Tessa Moses, Wilson C K Poon, Stuart A West, Martin J Cann

Journal: Nature Communications

PubMed ID: 39948360

Doi: 10.1038/s41467-025-56761-6

Products & Services: Gene Synthesis