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Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination

Authors: Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S Symington, Petr Cejka, Boris Pfander

Journal: Nature Communications

PubMed ID: 38570537

Doi: 10.1038/s41467-024-46951-z

Products & Services: Gene Synthesis

CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Authors: Annemart Koornneef, Kanika Vanshylla, Gijs Hardenberg, Lucy Rutten, Nika M Strokappe, Jeroen Tolboom, Jessica Vreugdenhil, Karin Feddes-de Boer, Aditya Perkasa, Sven Blokland, Judith A Burger, Wei-Chiao Huang, Jonathan F Lovell, Danielle van Manen, Rogier W Sanders, Roland C Zahn, Hanneke Schuitemaker, Johannes P M Langedijk, Frank Wegmann

Journal: Nature Communications

PubMed ID: 38605096

Doi: 10.1038/s41467-024-47492-1

Products & Services: Codon Optimization

Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders

Authors: Echuan Tan, Tao Wan, Qi Pan, Jianan Duan, Song Zhang, Ruijue Wang, Peng Gao, Jia Lv, Hui Wang, Dali Li, Yuan Ping, Yiyun Cheng

Journal: SCIENCE ADVANCES

PubMed ID: 38630829

Doi: 10.1126/sciadv.adl4336

Engineering allorejection-resistant CAR-NKT cells from hematopoietic stem cells for off-the-shelf cancer immunotherapy

Authors: Yan-Ruide Li, Yang Zhou 1, Jiaji Yu, Yichen Zhu, Derek Lee, Enbo Zhu, Zhe Li, Yu Jeong Kim, Kuangyi Zhou, Ying Fang, Zibai Lyu, Yuning Chen, Yanxin Tian, Jie Huang, Xinjian Cen, Tiffany Husman, Jae Min Cho, Tzung Hsiai, Jin J Zhou, Pin Wang, Benjamin R Puliafito, Sarah M Larson, Lili Yang

Journal: Molecular Therapy

PubMed ID: 38584391

Doi: 10.1016/j.ymthe.2024.04.005

Products & Services: Gene Synthesis

Mechanosensitive channel MscL gating transitions coupling with constriction point shift

Authors: Mingfeng Zhang, Siyang Tang, Xiaomin Wang, Sanhua Fang, Yuezhou Li

Journal: Protein Sci

PubMed ID: 38501596

Doi: 10.1002/pro.4965

Products & Services: Protein and Antibody Isolation

A selective Fibroblast Growth Factor Receptor 1/2 PROTAC degrader with 1 antitumor activity

Authors: Ying Kong , Xinyue Zhao , Zhaofu Wang , Siqi Yuan , Sheng Chen , Shidi Lou , Shichao Ma , Yunfeng Li , Xinghao Wang , Yangfeng Ge , Guobin Li , Hongbing Yang , Mengxi Zhao , Dandan Li , Hailong Zhang , Wenfu Tan , Juan Wang

Journal: Molecular cancer therapeutics

PubMed ID: 38647531

Doi: 10.1158/1535-7163.MCT-23-0719

Products & Services: Gene Synthesis

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Authors: Lijing Zhang, Xuping Xie, Hannan Luo, Runtong Qian, Yang Yang, Hongtao Yu, Jing Huang, Pei-Yong Shi, Qi Hu

Journal: Cell Discov

PubMed ID: 38594245

Doi: 10.1038/s41421-024-00673-0

Products & Services: Protein and Antibody Isolation

Online monitoring of protein refolding in inclusion body processing using intrinsic fluorescence

Authors: Chika Linda Igwe, Don Fabian Müller, Florian Gisperg, Jan Niklas Pauk, Matthias Kierein, Mohamed Elshazly, Robert Klausser, Julian Kopp, Oliver Spadiut, Eva Přáda Brichtová

Journal: Anal Bioanal Chem

PubMed ID: 38573344

Doi: 10.1007/s00216-024-05249-1

Products & Services: Codon Optimization

High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma

Authors: Ping Feng, Ying Wang, Na Liu, Yanming Chen, Yujun Hu, Zilu Huang, Ya Liu, Shuohan Zheng, Tongchao Jiang, Xiang Xiao, Wei Dai, Peng Huang, Yunfei Xia

Journal: Cell Death Differ

PubMed ID: 38589496

Doi: 10.1038/s41418-024-01287-5

Products & Services: Protein and Antibody Isolation

Immune response profiles from humans experimentally exposed to bites

Authors: Fernanda Fortes de Araujo, Maha Abdeladhim, Clarissa Teixeira, Kelly Hummer, Matthew D Wilkerson, Roseanne Ressner, Ines Lakhal-Naouar, Michael W Ellis, Claudio Meneses, Saule Nurmukhambetova, Regis Gomes, W David Tolbert, George W Turiansky, Marzena Pazgier, Fabiano Oliveira, Jesus G Valenzuela, Shaden Kamhawi, Naomi Aronson

Journal: Front Immunol

PubMed ID: 38633260

Doi: 10.3389/fimmu.2024.1335307

Products & Services: Protein and Antibody Isolation