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Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities

Authors: Sivan Kaminski Strauss, Ruthie Golomb, Donya Khoury, Noa Aharon-Hefetz, Hadar Meyer, Dayag Sheykhkarimli, Gianni Liti, Orna Dahan, Yitzhak Pilpel

Journal: Molecular Therapy

PubMed ID: 41689801

Doi: 10.1016/j.celrep.2026.116972

Products & Services: Gene Synthesis

Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform

Authors: Simon Christian Vinther, Antonia Resag, Karina Thao Thu Le, Claudia Christine Zelle-Rieser, Helen Strandt, Mette Galsgaard Malle, Stig Hill Christiansen, Barbara Del Frari, Theresia Stigger, Bastian Schilling, Jonas Wohlfarth, Steffen Thiel, Julián Valero, Patrizia Stoitzner, Jørgen Kjems

Journal: Molecular Therapy

PubMed ID: 41713595

Doi: 10.1016/j.jconrel.2026.114741

Products & Services: Custom Vector Construction

Functional characterization of secreted Schistosoma mansoni serpin SmSPI reveals Factor XIIa inhibition as evidenced by biochemical, and human plasma assays and supported by AI-assisted structural modelling

Authors: Lukáš Konečný, Kristýna Peterková, Ingrid Hrachovinová, Alex Loukas, Tomáš Macháček, Jan Dvořák, Lucie Jedličková

Journal: Molecular Therapy

PubMed ID: 41724421

Doi: 10.1016/j.ijpara.2026.104808

The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma

Authors: Brian D Tran, Irene Peris, Ethan Wurman, Averie Huang, Gabrielle Hodges Onishi, Jiang Hu, Rita A Avelar, Erika A Newman, Analisa DiFeo, Caitlin M O'Connor, Goutham Narla

Journal: Molecular Therapy

PubMed ID: 41707997

Doi: 10.1016/j.jbc.2026.111298

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells

Authors: Huanhuan Feng, Zhixue Li, Hongdao Zhang, Yuli Zheng, Beiying Xu, Yao Zhang, Lin Zou, Ligang Wu

Journal: Nucleic Acids Research

PubMed ID: 41728952

Doi: 10.1093/nar/gkag112

Identifying microbial protease allergens through protein language model-guided homology

Authors: Kumar Thurimella, Elena Wu, Chenhao Li, Daniel B Graham, Róisín M Owens, Damian R Plichta, Caroline L Sokol, Ramnik J Xavier, Sergio Bacallado

Journal: Molecular Therapy

PubMed ID: 41722567

Doi: 10.1016/j.cels.2025.101510

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo

Journal: Advanced Science

PubMed ID: 41521460

Doi: 10.1002/advs.202515724

Products & Services: Catalog Antibodies

Structural basis for the subtype-selectivity of KCa2.2 channel activators

Authors: Young-Woo Nam, Alena Ramanishka, Yang Xu, Rose Marie Haynes Yasuda, Joshua A Nasburg, Dohyun Im, Meng Cui, K George Chandy, Heike Wulff, Miao Zhang

Journal: Nature Communications

PubMed ID: 41507196

Doi: 10.1038/s41467-025-67232-3

Products & Services: Mutagenesis Services

A disulfide redox switch mechanism regulates glycoside hydrolase function

Authors: Marcele Pandeló Martins, Gustavo Henrique Martins, Felipe Jun Fuzita, João Paulo Menezes Spadeto, Renan Yuji Miyamoto, Felippe Mariano Colombari, Fabiane Stoffel, Luciano Graciani Dolce, Camila Ramos Dos Santos, Rodrigo Silva Araujo Streit, Antônio Carlos Borges, Rafael Henrique Galinari, Yoshihisa Yoshimi, Paul Dupree, Gabriela Felix Persinoti, Mariana Abrahão Bueno Morais, Mario Tyago Murakami

Journal: Nature Communications

PubMed ID: 41491304

Doi: 10.1038/s41467-025-67225-2

Products & Services: Custom Vector Construction

Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapy

Authors: Xianjun Li, Xuehan Li, Jiaqi Shi, Yingjing Li, Hanyu Zhang, Tianjun Chen, Hui Pang, Shuyuan Zhang, Shengnan Luo, Fengyi Liu, Shuang Li, Chujie Ding, Linlin Sun, Fan Xing, Tongsen Zheng

Journal: Nature biomedical engineering

PubMed ID: 41501251

Doi: 10.1038/s41551-025-01575-6

Products & Services: Recombinant Proteins