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Cnidaria XIAP activates caspase-mediated cell death

Authors: Yuan Chen, Meng Wu, Zihao Yuan, Qingyue Wang, Hang Xu, Li Sun

Journal: International Journal of Biological Macromolecules

PubMed ID: 40288723

Doi: doi.org/10.1016/j.ijbiomac.2025.143427

Products & Services: Protein and Antibody Isolation

Multi-level ROS regulation to activate innate and adaptive immune therapies

Authors: Ke-Ke Feng, Cheng-Lei Li, Yi-Fan Tu, Shi-Cheng Tian, Rui Xiong, Bai-Sheng Sa, Jing-Wei Shao

Journal: Chemical Engineering Journal

Doi: doi.org/10.1016/j.cej.2025.163429

Products & Services: Gene Synthesis

TRIM23 mediates cGAS-induced autophagy in anti-HSV defense

Authors: Dhiraj Acharya, Zuberwasim Sayyad, Helene Hoenigsperger, Maximilian Hirschenberger, Matthew Zurenski, Kannan Balakrishnan, Junji Zhu, Sebastian Gableske, Jiro Kato, Shen-Ying Zhang, Jean-Laurent Casanova, Joel Moss, Konstantin M J Sparrer, Michaela U Gack

Journal: Nature Communications

PubMed ID: 40360474

Doi: 10.1038/s41467-025-59338-5

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Authors: Hannah Van Hove, Chaim Glück, Wiebke Mildenberger, Ekaterina Petrova, Upasana Maheshwari, Philipp Häne, Victor Kreiner, Mitchell Bijnen, Caroline Mussak, Sebastian G Utz, Jeanne Droux, Florian Ingelfinger, Christian Ashworth, Sebastian A Stifter, Elsa Roussel, Iva Lelios, Marijne Vermeer, Sheng-Fu Huang, Quanyu Zhou, Zhenyue Chen, Charlotte Calvet, Soline Bourgeois, Johanna Schaffenrath, Daniel Razansky, Jean X Juang, Kenichi Asano, Pawel Pelczar, Sarah Mundt, Bruno Weber, Susanne Wegener, Sonia Tugues, Christian Stockmann, Burkhard Becher, Annika Keller, Mohamad El Amki, Melanie Greter

Journal: Immunity

PubMed ID: 40315842

Doi: 10.1016/j.immuni.2025.04.003

Products & Services: Gene Synthesis

Structural basis for hepatitis E virus neutralization by potent human antibodies

Authors: Luis M Molinos-Albert, Eduard Baquero, Cyril Planchais, Virginie Doceul, Hicham El Costa, Estelle Mottez, Vincent Mallet, Stanislas Pol, Matthew L Albert, Nicole Pavio, Cécile Alanio, Jordan D Dimitrov, Hugo Mouquet

Journal: SCIENCE ADVANCES

PubMed ID: 40333967

Doi: 10.1126/sciadv.adu8811

Products & Services: Peptide Synthesis

A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury

Authors: Yushuo Xiao, Zhijian Tong, Huidie Xu, Zhouyan Jia, Chen Wang, Yang Cao, Liangliang Song, Siyu Hao, Jing Yang, Yihao Zhou, Yunhao Xie, Peng Wu, Tong He, Yancai Wu, Robert B Petersen, Anlin Peng, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40315322

Doi: 10.1126/sciadv.adt3943

Products & Services: Peptide Synthesis

Biomimetic culture substrates for modelling homeostatic intestinal epithelium in vitro

Authors: Sorosh Abdollahi, Bahareh Zarin, Maryam Vatani, Fereshteh Vajhadin, Mohsen Hassani, Pezhman Jalali, Keekyoung Kim, Amir Sanati-Nezhad

Journal: Nature Communications

PubMed ID: 40316543

Doi: 10.1038/s41467-025-59459-x

Products & Services: Molecular Biology Reagents

Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

Authors: Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Journal: Immunity

PubMed ID: 40359940

Doi: 10.1016/j.immuni.2025.04.020

Products & Services: Protein and Antibody Isolation

Neuron-targeted gene therapy rescues multiple phenotypes of STXBP1-related disorders in mice and is well tolerated in nonhuman primates

Authors: Rangoli Aeran, Annie Tanenhaus, Sheila M S Sears, Nathan J Moerke, Adam Miller, Camille Artur, Yosr Bouhlal, Peter F Bove, Alexander J Diaz de Arce, Saki Shimizu, Jason Le, Keith Place, Dixon Hoffelt, Tselmeg Amarlkhagva, Jennifer Su, Ming Chen, Brooke A Babineau, John McLaughlin, Myat Soe, Warren Macdonald, I Winnie Lin, Dhruv Bole, Kristen M Valentine, Elizabeth Hallam, Puja Dhanota, Serena Liu, Steven A Tan, Ben Zhao, Raghavendra Hosur, Maria Candida Vila, Suresh Poda, Archana Belle, Stephanie Tagliatela

Journal: Molecular Therapy

PubMed ID: 40349107

Doi: 10.1016/j.ymthe.2025.05.011

Import mechanism of peroxisomal proteins with an N-terminal signal sequence

Authors: Michael L Skowyra , Tom A Rapoport

Journal: Nature Cell Biology

PubMed ID: 40346349

Doi: 10.1038/s41556-025-01662-5

Products & Services: Peptide Synthesis