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Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate

Authors: Fan Chen, Xue-Fei Tian, Teng Yang, Yu-Jie Dai, Da-Yuan Chen, Hong-Bo Chen, Takaya Shimura, Xin-Fang Li, Chu-Lin Sha, Qing Ji, Jun Cao, Mei-Yu Fang, Jin-Biao Shang, Jian-Min Fang, Ye Lu, Wei-Hui Zheng, Peng Guo, Wei-Hong Tan

Journal: Advanced Science

PubMed ID: 40539828

Doi: 10.1002/advs.202504851

Products & Services: Monoclonal Antibody Services

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage

Authors: Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing

Journal: Advanced Science

PubMed ID: 40548893

Doi: 10.1002/advs.202409307

Products & Services: PCR Cloning and Subcloning

Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication

Authors: Klara Lenart, Hendrik Feuerstein, Mariana Prado Marmorato, Laura Perez Vidakovics, Gerald McInerney, Mimi Guebre-Xabier, Jessica F Trost, Bengt Eriksson, Gale Smith, Nita Patel, Karin Loré

Journal: Nature Communications

PubMed ID: 40562777

Doi: 10.1038/s41467-025-60885-0

Products & Services: Gene Synthesis

Single-Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Authors: Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu

Journal: Advanced Science

PubMed ID: 40470730

Doi: 10.1002/advs.202500216

Products & Services: PCR Cloning and Subcloning

Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer

Authors: Ze Mi, Juan Chen, Zhewen Zhang, Jiahao Liu, Yiyi Lei, Hongpei Tan, Wei Li, Xiaoyuan Chen, Pengfei Rong

Journal: SCIENCE ADVANCES

PubMed ID: 40531967

Doi: 10.1126/scitranslmed.ado8395

Products & Services: DNA Sequencing

Chemokines kill bacteria without triggering antimicrobial resistance by binding anionic phospholipids

Authors: Sergio M Pontejo, Sophia Martinez, Allison Zhao, Kevin Barnes, Jaime de Anda, Haleh Alimohamadi, Ernest Y Lee, Acacia F Dishman, Brian F Volkman, Gerard C L Wong, David N Garboczi, Angela Ballesteros, Philip M Murphy

Journal: SCIENCE ADVANCES

PubMed ID: 40479071

Doi: 10.1126/sciadv.ads2675

Products & Services: Plasmid DNA Preparation

Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa

Authors: Marius Benedens, Cristian Rosales-Hernandez, Sabine A P Straathof, Jennifer Loschwitz, Otto Berninghausen, Giovanni Maglia, Roland Beckmann, Alexej Kedrov

Journal: Nature Communications

PubMed ID: 40473691

Doi: 10.1038/s41467-025-60605-8

Products & Services: Gene Synthesis

The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in Drosophila

Authors: Anish Bose, Keaton Schuster, Chandril Kodali, Surabhi Sonam, Rachel K Smith-Bolton

Journal: SCIENCE ADVANCES

PubMed ID: 40479065

Doi: 10.1126/sciadv.ads5743

Products & Services: PCR Cloning and Subcloning

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI

Authors: Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren

Journal: SCIENCE ADVANCES

PubMed ID: 40540557

Doi: 10.1126/sciadv.adw0698

Products & Services: Custom Vector Construction

Molecular basis of the hepatobiliary tropism of typhoid toxin promoting Salmonella pathogenicity

Authors: Hwa Young Kim, Gi Young Lee, Andrew J Thompson, Ryan McBride, Dah-Jiun Fu, James C Paulson, Jeongmin Song

Journal: SCIENCE ADVANCES

PubMed ID: 40479051

Doi: 10.1126/sciadv.adt2040

Products & Services: Catalog Antibodies