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Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity

Authors: Yujiao Zu; Ling Zhao; Lei Hao; Yehia Mechref; Masoud Zabet-Moghaddam; Peter A. Keyel; Mehrnaz Abbasi; Dayong Wu; John A. Dawson; Ruiwen Zhang; Shufang Nie; Naima Moustaid-Moussa; Mikhail G. Kolonin; Alexes C. Daquinag; Luis Brandi; Irfan Warraich; Susan K. San Francisco; Xiaocun Sun; Zhaoyang Fan; Shu Wang

Journal: Journal of controlled release : official journal of the Controlled Release Society

PubMed ID: 33766692

Doi: 10.1016/j.jconrel.2021.03.022

Products & Services: Peptide Synthesis

AI-assisted design of ligands for lipocalin-2

Authors: Jacopo Sgrignani; Sara Buscarini; Patrizia Locatelli; Concetta Guerra; Alberto Furlan; Yingyi Chen; Giada Zoppi; Andrea Cavalli

Journal: Frontiers in Immunology

PubMed ID: 41019093

Doi: 10.3389/fimmu.2025.1631868

Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against nonsmall cell lung cancer

Authors: Jia-Hao Tao, Jun Zhang, Chun-Yan Tang, Jia-Xi Duan, Wen-Jing Zhong, Chen-Yu Zhang, Yu-Biao Liu, Jin Ling, Hua-Shun Li, Yong Zhou, Cha-Xiang Guan

Journal: Cancer gene therapy

PubMed ID: 40913086

Doi: 10.1038/s41417-025-00957-x

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing in colonic diseases

Authors: Qiang Gao, Yunxia Gao, Yingui Cao, Haiting Xu, Ya Ma, Menghang Zu, Qiang Yang, Kun Yang, Zhenhua Zhu, Chao Liu, Xiaoxiao Shi, Rui L Reis, Subhas C Kundu, Shengyun Ma, Hesong Han, Bo Xiao

Journal: SCIENCE ADVANCES

PubMed ID: 41004579

Doi: 10.1126/sciadv.adw9275

Products & Services: Catalog Gene Editing

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Authors: Lingling Geng, Jiale Ping, Ruochen Wu, Haoteng Yan, Hui Zhang, Yuan Zhuang, Taixin Ning, Jun Wang, Chuqian Liang, Jiachen Zhang, Qingqing Chu, Jing Zhang, Yifan Wen, Yaobin Jing, Shuhui Sun, Qin Qiao, Qian Zhao, Qianzhao Ji, Shuai Ma, Yusheng Cai, Yandong Zheng, Zhiran Zou, Zhiqing Diao, Mingheng Li, Hao Zhang, Jianli Hu, Liangzheng Fu, Wang Kang, Ruijun Bai, Hongkai Zhao, Sheng Zhang, Yingjie Ding, Jinghui Lei, Wei Wang, Yun Ji, Bo Gou, Guoqiang Sun, Jian Yin, Pengze Yan, Hao Li, Zehua Wang, Shikun Ma, Zunpeng Liu, Hezhen Shan, Qiaoran Wang, Tianling Cao, Shanshan Yang, Cui Wang, Ping Yang, Yanling Fan, Yanxia Ye, Jinghao Hu, Mengmeng Jiang, Ye Wang, Kan Liu, Yujing Li, Yuanxiang Li, Jingyi Li, Weimin Ci, Zi-Bing Jin, Xiaobing Fu, Xu Zhang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Si Wang, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Journal: Cell

PubMed ID: 40570836

Doi: 10.1016/j.cell.2025.06.001

Products & Services: Synthetic Guide RNA

RING-Between-RING-Type E3 Ligase Ariadne-Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein

Authors: Wenli Li, Chenchen Zhong, Jiangning Duan, Changyi Zhan, Zhaolei Li, Xinyu Zhang, Dingliang Zhang, Deshui Liu, Zhiyan Wen, Xiaofei Zhao, Meng Yang, Dawei Li, Yongliang Zhang

Journal: Advanced Science

PubMed ID: 40908568

Doi: 10.1002/advs.202509942

Functional characterisation of missense ceruloplasmin variants and real-world prevalence assessment of Aceruloplasminemia using population data

Authors: Nicole Ziliotto; Sara Lencioni; Martina Cirinciani; Alan Zanardi; Massimo Alessio; Giulia Sold ; Eleonora Da Pozzo; Rosanna Asselta; Andrea Caricasole

Journal: EBioMedicine

PubMed ID: 40043514

Doi: 10.1016/j.ebiom.2025.105625

Functional characterisation of missense ceruloplasmin variants and real-world prevalence assessment of Aceruloplasminemia using population data

Authors: Nicole Ziliotto; Sara Lencioni; Martina Cirinciani; Alan Zanardi; Massimo Alessio; Giulia Sold ; Eleonora Da Pozzo; Rosanna Asselta; Andrea Caricasole

Journal: EBioMedicine

PubMed ID: 40043514

Doi: 10.1016/j.ebiom.2025.105625

A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Authors: Thu-Thuy Nguyen; Tae Heung Kim; Emily Bencosme-Cuevas; Jacquie Berry; Alex Samuel Kiarie Gaithuma; Moiz Ashraf Ansari; Tae Kwon Kim; Lucas Tirloni; Zeljko Radulovic; James J. Moresco; John R. Yates; Albert Mulenga

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services

A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services