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Optimizing a human monoclonal antibody for better neutralization of SARS-CoV-2

Authors: Qian Wang, Yicheng Guo, Ryan G Casner, Jian Yu, Manoj S Nair, Jerren Ho, Eswar R Reddem, Ian A Mellis, Madeline Wu, Chih-Chen Tzang, Hsiang Hong, Yaoxing Huang, Lawrence Shapiro, Lihong Liu, David D Ho

Journal: Nature Communications

PubMed ID: 40615407

Doi: 10.1038/s41467-025-61472-z

Products & Services: Gene Synthesis

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria

Authors: Belen Sotomayor, Thomas C Donahue, Sai Pooja Mahajan, May N Taw, Sophia W Hulbert, Erik J Bidstrup, D Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A Alabi, Parastoo Azadi, Jeffrey J Gray, Michael C Jewett, Lai-Xi Wang, Matthew P DeLisa

Journal: Nature Communications

PubMed ID: 40610439

Doi: 10.1038/s41467-025-61440-7

Products & Services: Peptide Synthesis

Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses

Authors: Tobias Plowman, Tom Hofland, Callum Hall, Rachael Thompson, Judith Pape, Kevin W Ng, Laura Doglio, George Kassiotis

Journal: SCIENCE ADVANCES

PubMed ID: 40614216

Doi: 10.1126/sciimmunol.adr1105

Products & Services: Gene Synthesis

The mitotic chromosome periphery modulates chromosome mechanics

Authors: Tania Mendonca, Roman Urban, Kellie Lucken, George Coney, Neil M Kad, Manlio Tassieri, Amanda J Wright, Daniel G Booth

Journal: Nature Communications

PubMed ID: 40640170

Doi: 10.1038/s41467-025-61755-5

Products & Services: Gene Synthesis

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors

Authors: Yixuan Zhong, Huihui Tao, Yu Zhang, Binbin He, Haizhan Jiao, Dandan Wang, Maikun Teng, Hongli Hu, Qiong Guo, Yuyong Tao

Journal: Nature Communications

PubMed ID: 40659608

Doi: 10.1038/s41467-025-61695-0

Rice E3 ubiquitin ligase BLAST AND BTH-INDUCED 1 targets jasmonic acid signaling co-repressors to release Myelocytomatosis protein 2 for modulating immune responses against blast fungus

Authors: Yan Bi , Yuqing Yan , Hui Wang , Leeza Tariq , Dayong Li , Fengming Song

Journal: International Journal of Biological Macromolecules

PubMed ID: 40543771

Doi: doi.org/10.1016/j.ijbiomac.2025.145363

Products & Services: Catalog Peptides

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Authors: Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng

Journal: Advanced Science

Doi: doi.org/10.1002/advs.202416809

Products & Services: Peptide Synthesis

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao

Journal: Cell Communication and Signaling

PubMed ID: 40514668

Doi: 10.1186/s12964-025-02289-7

Products & Services: Protein and Antibody Isolation

Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation

Authors: Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Mingwei Lv, Yirou Zhang, Yiteng Lu, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Tianlei Ying, Yanling Wu, Jiaxu Hong

Journal: Cellular & molecular immunology

PubMed ID: 40500403

Doi: 10.1038/s41423-025-01305-7

Products & Services: Protein and Antibody Isolation

An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment

Authors: Qingyun Mo, Haotian Zheng, Chuanquan Liu, Yuzhi Sun, Zhicheng Cao, Renwang Sheng, Yanan Zhang, Mingyue Wang, Baian Kuang, Ludvig J Backman, Jiaxiang Li, Wei Zhang, Jialin Chen

Journal: Acta Biomaterialia

PubMed ID: 40409996

Doi: 10.1016/j.actbio.2025.05.040

Products & Services: Recombinant Proteins