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Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability

Authors: Hui Cao, Xin Meng, Yuan Ma, Zhe Li, Xinyu Xu, Jiaqi Fu, Qingpeng Zhang, Hanlin Wei, Peng Liang, Dingyou Lu, Jinyu Li, Baoli Yin, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song

Journal: Nature Communications

PubMed ID: 41173886

Doi: 10.1038/s41467-025-64633-2

Products & Services: Catalog Peptides

TOPO-seq reveals DNA topology-induced off-target activity by Cas9 and base editors

Authors: Min Duan, Pan Gao, Yi-Zhou Zhang, Yu-Long Hu, Lei Zhou, Zhong-Chen Xu, Hou-Yuan Qiu, Xiao-Han Tong, Rui-Jin Ji, Xin-Lin Lei, Hao Yin, Cun-Lan Guo, Ying Zhang

Journal: Nature Chemical Biology

PubMed ID: 40175512

Doi: 10.1038/s41589-025-01867-7

Products & Services: Synthetic Guide RNA

Guidelines in the Preparation of Fully Synthetic, Human Single-Domain Antibody Phage Display Libraries

Authors: Mark A. Tornetta; Brian P. Whitaker; Olivia M. Cantwell; Peter N. Haytko; Eileen D. Pisors; Fulai Zhou; Mark L. Chiu

Journal: Antibodies

PubMed ID: 40843683

Doi: 10.3390/antib14030071

Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance

Authors: Vincent N. Azzolino; Ala M. Shaqra; Akbar Ali; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: Viruses

PubMed ID: 39339895

Doi: 10.3390/v16091419

Products & Services: Peptide Synthesis

Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance

Authors: Vincent N. Azzolino; Ala M. Shaqra; Akbar Ali; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: Viruses

PubMed ID: 39339895

Doi: 10.3390/v16091419

Products & Services: Peptide Synthesis

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria

Authors: Hannah E. Snoke; Stephanie M. Reeve; Suresh Dharuman; Miranda J. Wallace; Victoria C. Loudon; Ying Zhao; John J. Bowling; Patricia A. Murphy; Brett Waddell; Robin B. Lee; J rgen B. Bulitta; Richard E. Lee

Journal: ACS Infectious Diseases

PubMed ID: 41116192

Doi: 10.1021/acsinfecdis.5c00635

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria

Journal: ACS Infectious Diseases

PubMed ID: 41116192

Doi: 10.1021/acsinfecdis.5c00635

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria

Journal: ACS Infectious Diseases

PubMed ID: 41116192

Doi: 10.1021/acsinfecdis.5c00635

The fibroblast-driven melanoma/Treg vitiligo mouse model is effectively suppressed by IFN blocking antibody

Authors: Yuhua Xie; Jun Cui; Yanhua Lu; Yingxue Du; Jianmin Chang

Journal: Frontiers in Medicine

PubMed ID: 41080931

Doi: 10.3389/fmed.2025.1677626

Products & Services: Monoclonal Antibody Services

Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity

Authors: Yujiao Zu; Ling Zhao; Lei Hao; Yehia Mechref; Masoud Zabet-Moghaddam; Peter A. Keyel; Mehrnaz Abbasi; Dayong Wu; John A. Dawson; Ruiwen Zhang; Shufang Nie; Naima Moustaid-Moussa; Mikhail G. Kolonin; Alexes C. Daquinag; Luis Brandi; Irfan Warraich; Susan K. San Francisco; Xiaocun Sun; Zhaoyang Fan; Shu Wang

Journal: Journal of controlled release : official journal of the Controlled Release Society

PubMed ID: 33766692

Doi: 10.1016/j.jconrel.2021.03.022

Products & Services: Peptide Synthesis