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Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1

Authors: Francisco G Sanchez-Conde, Matthew R Goodrich, Olivia M Stack, Louis N R Goldberg, Pamela K Ruzycki, Abhilasha Jain, Eric N Jimenez-Vazquez, David K Jones

Journal: Molecular Therapy

PubMed ID: 41708004

Doi: 10.1016/j.jbc.2026.111296

Products & Services: Mutagenesis Services

AE-MXene-modified titanium alloy promotes osseointegration by regulating the AMPKMTOR-autophagy pathway in macrophage

Authors: Rui Chao, Lei Sun, Xinyu Xu, Zhan Liu, Xinyi Xu, Zhen Ren, Xinwei Chen, Weifeng Xu, Xuzhuo Chen, Ying Hu, Shanyong Zhang

Journal: Journal of nanobiotechnology

PubMed ID: 41634773

Doi: 10.1186/s12951-026-04080-3

Products & Services: Protein Electrophoresis and Western

Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model

Authors: Ziyu Zhang, Man Wang, Fangzhi Tan, Liyan Zhang, Xiaohan Wang, Xiangyan Chen, Jia Han, Nianci Li, Qiuhan Sun, Yicheng Lu, Zhiping Cui, Zuhong He, Jieyu Qi, Renjie Chai

Journal: Med

PubMed ID: 41763223

Doi: 10.1016/j.medj.2026.101001

Products & Services: Protein Electrophoresis and Western

A novel two-component system regulates shikimate pathway for thermal adaptation in Thermus thermophilus

Authors: Xuying Bu, Yuwen Guo, Xiangyu Tian, Yuan Shao, Changyou Li, Pan Zhang, Yunxiang Liang, Yingjun Li

Journal: Nucleic Acids Research

PubMed ID: 41693563

Doi: 10.1093/nar/gkag116

Products & Services: Protein and Antibody Isolation

The RNA methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) on IL1B mRNA to promote transcript stability

Authors: Jiayun Wang, Lingyan Yan, Rong Jia, Jihua Guo

Journal: Molecular Therapy

PubMed ID: 41707999

Doi: 10.1016/j.jbc.2026.111290

Products & Services: Protein Electrophoresis and Western

A Specific Sinorhizobium Flagellin Suppresses Legume Nodulation Through Immune Activation

Authors: Li Liu, Yaohua Li, Shuangcheng Ye, Chuanzheng Wei, Ziang Yan, Huanhui Yang, Hui Zhu, Gary Stacey, Yangrong Cao

Journal: Plant Biotechnology Journal

PubMed ID: 41636391

Doi: 10.1111/pbi.70576

Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors

Authors: Joseph J Porter, Wooree Ko, Emily G Sorensen, Zachary Cheung, Kari Thrasher, Tyler Couch, Jeffrey T Gabell, Victoria Shwe, Julia Hyatt, Jennasea B Licata, Luke K Peterson, David A Dean, John D Lueck

Journal: Nucleic Acids Research

PubMed ID: 41641696

Doi: 10.1093/nar/gkag082

Divergent stem cell mechanisms govern the primary body axis and appendage regeneration in the axolotl

Authors: Liqun Wang, Li Song, Chao Yi, Jing Zhou, Zhouying Yong, Yan Hu, Xiangyu Pan, Na Qiao, Hao Cai, Wandong Zhao, Rui Zhang, Lieke Yang, Lei Liu, Guangdun Peng, Elly M Tanaka, Hanbo Li, Yanmei Liu, Ji-Feng Fei

Journal: SCIENCE ADVANCES

PubMed ID: 41650255

Doi: 10.1126/sciadv.adx5697

Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex

Authors: Hao-Chi Hsu, Isabelle Bonnet, Ruslana Bryk, Huilin Li

Journal: Molecular Therapy

PubMed ID: 41690596

Doi: 10.1016/j.jbc.2026.111284

Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist

Authors: Eric Gibbs, Bjarne Feddersen, Kayla J Kindig, David Seiferth, Philip C Biggin, Sudha Chakrapani

Journal: SCIENCE ADVANCES

PubMed ID: 41686897

Doi: 10.1126/sciadv.aeb2036