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E. coli-mediated expedient biosynthesis of biotin-labeled ubiquitin probe enables activity-based profiling of deubiquitinases in cytoplasmic and nuclear compartments

Authors: Shuai Peng, Shaowen Wang, Xiaotong Liu, Hongrui Xu, Guoqiang Xu, Jia-bin Li

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.111760

Products & Services: Codon Optimization Gene Synthesis PCR Cloning and Subcloning

Retrograde transport of neurotrophin receptor TrkB-FL inducedby excitotoxicity regulates Golgi stability and is a target forstroke neuroprotection

Authors: Gema María Esteban-Ortega, Elena Torres-Campos, Margarita Díaz-Guerra

Journal: Cell death & disease

PubMed ID: 40883288

Doi: 10.1038/s41419-025-07990-6

Products & Services: Peptide Synthesis Protein and Antibody Isolation

Lung metastasis and recurrence is mitigated by CARmacrophages, in-situ-generated from mRNA delivered by small extracellular vesicles

Authors: Yuchen Xiao, Tianchuan Zhu, Zhenxing Chen, Xi Huang

Journal: Nature Communications

PubMed ID: 40759657

Doi: 10.1038/s41467-025-62506-2

Products & Services: Custom DNA/RNA Oligos

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin.

Authors: Jing-Xiao Wang, Xiao-Yu Xu, Hong-Ke Dong, Yi-Ming Wang, Min Dai, Bing Zhou, Yue-Hua Li, Guo-Qing Zhu, Xiao-Qing Xiong

Journal: Journal of extracellular vesicles

PubMed ID: 40767027

Doi: 10.1002/jev2.70146.

Products & Services: Custom RNAi Services

The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation

Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris

Journal: Journal of the American Chemical Society

PubMed ID: 40774922

Doi: doi.org/10.1021/jacs.5c08814

Products & Services: Gene Synthesis

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens

Journal: Nature Cell Biology

PubMed ID: 40715440

Doi: 10.1038/s41556-025-01712-y

Products & Services: Gene Synthesis

Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Authors: Gang Shen, Zhenzhen Fang, Fuyan Hong, Mian Wu, Jing Zhang, Jinhong Wang, Chuan Bai, Wencan Chen, Xia Yang, Chunhua Deng, Haibing Chen, Guoquan Gao, Ti Zhou

Journal: Communications Biology

PubMed ID: 40783594

Doi: 10.1038/s42003-025-08607-6.

Products & Services: Protein and Antibody Isolation

Laodelphax striatellus salivary sheath protein Lsactin triggers defense response in plants

Authors: Liangxuan Qi, Jing Li, Han Wang, Jing Li, Xinyang Tan, Zhichang Zhao, Sicong Zhou, Jichao Fang, Rui Ji

Journal: Insect biochemistry and molecular biology

PubMed ID: 40543628

Doi: 10.1016/j.ibmb.2025.104351

Products & Services: Polyclonal Antibody Services

Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment

Authors: Zhuorun Song, Shunyi Lu, Yuqi Yang, Zijun Chen, Youdong Chen, Jie Cao, Zimin Zhang, Jun Ge, Huilin Yang, Liang Cheng