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G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

Authors: Harrison A Fuchs, Yunhui Peng, Shine Ayyapan, Ruben Rosas, Houfang Zhang, Anna R Panchenko, Catherine A Musselman

Journal: Nucleic Acids Research

PubMed ID: 41533587

Doi: 10.1093/nar/gkaf1381

Products & Services: Mutagenesis Services

A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

Authors: Shihong Zhang, Tzu-Hao Tang, Sinéad Kinsella, Francesco Mazziotta, Michael T Schweizer, Megan S McAfee, Ariunaa Munkhbat, Yapeng Su, Valentin Voillet, Lauren E Martin, Colton W Smith, Yuta Asano, Menna Hailemariam, Jakob Bakhtiari, Bo Lee, Cecilia Yeung, Hung Chen, Alessandro M Rizzi, Daniel G Chen, Kelsey Furiya, Nick Horst, Tianzi Zhang, Phung Le, Kelly McKenna, Shannon K Oda, Anthony Rongvaux, Phillip D Greenberg, Thomas M Schmitt, Aude G Chapuis

Journal: Nature Communications

PubMed ID: 41484084

Doi: 10.1038/s41467-025-67446-5

Products & Services: DNA Sequencing

Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization

Authors: Aurélie Favarin, Rayan Said, Hong Wang, Emilie Zeine, Amaury Pierrard, Julien Pernier, Hemalatha Narassimprakash, Stéphane Roméro, Alexis M Gautreau, René-Marc Mège, Christophe Le Clainche

Journal: SCIENCE ADVANCES

PubMed ID: 41477870

Doi: 10.1126/sciadv.ady4863

Products & Services: PCR Cloning and Subcloning

Polyamine-dependent metabolic shielding regulates alternative splicing

Authors: Amaia Zabala-Letona, Mikel Pujana-Vaquerizo, Belen Martinez-Laosa, Maria Ponce-Rodriguez, Saioa Garcia-Longarte, Isabel Mendizabal, Ana Gimeno, Malgorzata Rogalska, Joycelyn Tan, Diana Cabrera, Sebastiaan van Liempd, Pilar Ximenez-Embun, Sergio Espinosa, Maider Fagoaga-Eugui, Francesca Peccati, Maciej Zakrzewski, Ianire Astobiza, Mikel Arana-Castañares, Sarah Cherkaoui, Maria Sendino, Inés Martín-Barros, Amaia Ercilla, Laura Bozal-Basterra, Onintza Carlevaris, Amaia Arruabarrena-Aristorena, Encarnación Pérez-Andrés, Telmo Santamaría-Zamorano, Juan A Ferrer-Bonsoms, Fernando Carazo, Maciej Cieśla, Cesar Lobato, Joan Seoane, Natalia Martín-Martín, Rosa Barrio, James D Sutherland, Ana M Aransay, Juan Manuel Falcón-Pérez, Barbara Martínez-Pastor, Angel Rubio, Francisco J Blanco, Michael D Hogarty, Raphael J Morscher, Edurne Berra, Remigiusz A Serwa, Jesús Jiménez-Barbero, Gonzalo Jiménez-Osés, Alejo Efeyan, Lydia Finley, Jose M Lizcano, Javier Muñoz, Juan Valcarcel, Arkaitz Carracedo

Journal: Nature

PubMed ID: 41535471

Doi: 10.1038/s41586-025-09965-1

Products & Services: Gene Synthesis

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

Authors: Christopher J. Lupton, Charles Bayly-Jones, Shuqi Dong, Terrance Lam, Wentong Luo, Gareth D. Jones, Chantel Mastos, Nicholas J. Frescher, San S. Lim, Alastair C. Keen, Luke E. Formosa, Hari Venugopal, Yong-Gang Chang, Michelle L. Halls, Andrew M. Ellisdon

Journal: Cell

PubMed ID: 41512879

Doi: 10.1016/j.cell.2025.12.005

Products & Services: Molecular Biology Reagents

Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk.

Authors: Huijian Yang, Biao Yu, Ruiyang Li, Yang Hong, Mingzhu Shen, Tianzhuo Shen, Xiuhui Wang, Han Liu, Guangchao Wang, Ke Xu, Yuhai Ma, Mengmeng Li, Jiacan Su

Journal: Journal of nanobiotechnology

PubMed ID: 41530784

Doi: 10.1186/s12951-026-04021-0

Products & Services: Protein Electrophoresis and Western

WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity

Authors: Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang, Yong Chen, Yanjing Li

Journal: Nature Communications

PubMed ID: 41565645

Doi: 10.1038/s41467-026-68623-w

Products & Services: Custom DNA/RNA Oligos

An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection

Authors: Zihan Wang, Fuwan Yang, Shuai Zeng, Rui Sun, Qifei Hu, Yichen Du

Journal: Lab on a chip

PubMed ID: 41439322

Doi: 10.1039/D5LC01096A

Products & Services: Synthetic Guide RNA

Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours.

Authors: James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel Dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki

Journal: Molecular Therapy

PubMed ID: 41566775

Doi: 10.1016/j.ymthe.2026.01.019

Products & Services: Protein portfolio

All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery

Authors: Parul Sirohi, Brooke E Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y Ma, Chinmay S Potnis, Soumen Saha, Xinghai Li, Max R Ney, Sarah Y Kim, Joshua J Milligan, Lixin Fan, Matthew L Becker, Daniel Reker, Ashutosh Chilkoti

Journal: Advanced Science

PubMed ID: 41549226

Doi: 10.1002/advs.202517048

Products & Services: Catalog Antibodies