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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Authors: Yongliang Tong , Runqiu Chen , Xinrong Lu , Cuiying Chen , Guiqin Sun , Xiaolu Yu , Shaoxian Lyu , Meiqing Feng , Yiru Long , Likun Gong , Li Chen

Journal: Int J Biol Macromol

PubMed ID: 39824395

Doi: 10.1016/j.ijbiomac.2025.139953

Products & Services: Gene Synthesis

Restoring tumor antigenicity activates the “bystander” T cell immune cycle

Authors: Yifan Yang , Qiumin Yu , Haoyu Zhang , Yuchen Liu , Hexuan Wang , Ningyi Yang , Yulian Shi , Wanli Zhang , Zijie Wu , Shitong Huang , Wenbin Xie , Ran Duan , Qiuli Mao , Xupeiyao Shi , Zheng Gao , Xiaoning Wang , Hanlin Guo , Lingxiao Chen , Yi Han , Ximing Li , Liyuan Chen , Siqi Tang , Ying Fan , Wenbing Yao , Hong Tian , Xiangdong Gao

Journal: J Control Release

PubMed ID: 39894265

Doi: 10.1016/j.jconrel.2025.01.094

Products & Services: Gene Synthesis

Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy

Authors: Nailin Yang , Shumin Sun , Jiachen Xu , Fei Gong, Huali Lei , Yu Hao , Zifan Pei , Chenya Wang , Qiao Yu , Jihu Nie , Nan Jiang , Caifang Ni , Liang Cheng

Journal: Adv Mater

PubMed ID: 10.1002/adma.202414929

Doi: 10.1002/adma.202414929

Products & Services: Protein and Antibody Isolation

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

Authors: Joan A Chick, Nadege N Abongdia, Robert A Shey, Tobias O Apinjoh

Journal: Heliyon

PubMed ID: 39906795

Doi: 10.1016/j.heliyon.2025.e42014

Products & Services: Bacterial Expression

TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy

Authors: Chunyang Cai, Chufeng Gu, Shuai He, Chunren Meng, Dongwei Lai, Jingfa Zhang, Qinghua Qiu

Journal: Clinical epigenetics

PubMed ID: 38172938

Doi: 10.1186/s13148-023-01619-1

Products & Services: Protein and Antibody Isolation

Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity

Authors: Gage M. J. Fairlie, Kha M. Nguyen, Sung-Eun Nam, Alexandria L. Shaw, Matthew A. H. Parson, Hannah R. Shariati, Xinyin Wang, Meredith L. Jenkins, Michael Gong, John E. Burke & Calvin K. Yip

Journal: Nature Communications

PubMed ID: 39779760

Doi: 10.1038/s41467-025-55828-8

Products & Services: Protein and Antibody Isolation

Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii

Authors: Corentin Blanchais, Carine Pages, Manuel Campos, Kenza Boubekeur, Rachel Contarin, Mathias Orlando, Patricia Siguier, Maria-Halima Laaberki, François Cornet, Xavier Charpentier, Philippe Rousseau

Journal: Nucleic Acids Research

PubMed ID: 39777461

Doi: 10.1093/nar/gkae1255

Products & Services: Gene Synthesis

Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading

Authors: Gabriele Olivieri, Giuditta Dal Cortivo, Rebecca Del Conte, Serena Zanzoni, Valerio Marino, Daniele Dell'Orco, Francesca Cantini

Journal: International Journal of Biological Macromolecules

PubMed ID: 39586446

Doi: doi.org/10.1016/j.ijbiomac.2024.138003

Products & Services: Peptide Synthesis

Intestine-Decipher Engineered Capsules Protect Against Sepsis-induced Intestinal Injury via Broad-spectrum Anti-inflammation and Parthanatos Inhibition

Authors: Yan Yan, Bin Li, Qiuxia Gao, Miao Wu, Hua Ma, Jiawei Bai, Chengtai Ma, Xinyu Xie, Yuan Gong, Lingqi Xu, Xiaoxue Li, Wei Wang, Yanqiu Wu, Jiamei Wang, Huanhuan Wang, Yi Feng, Yunlong Zhang, Peiran Li, Huimin Shi, Fei Ma, Yue Jia, Han Duan, Xinting Fu, Wenying Wang, Liying Zhan, Xianjin Du, Huiting Zhou, Yuhui Liao

Journal: Advanced Science

PubMed ID: 39836501

Doi: 10.1002/advs.202412799

Products & Services: Protein Electrophoresis and Western

Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity

Authors: Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Smita S. Chandran, Tatiana J. Rosales, W. W. J. Gihan Perera, Bassant Eldaly, William T. Murray, Steven A. Corcelli, Evgenii L. Kovrigin, Christopher A. Klebanoff & Brian M. Baker

Journal: Nature Communications

PubMed ID: 39833157

Doi: 10.1038/s41467-025-56004-8

Products & Services: Neoantigen Peptide Service