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Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates ﬁbrilinduced cellular stress

Authors: Greeshma Jain, Marina Trombetta-Lima, Irina Matlahov, Hennrique Taborda Ribas, Tingting Chen, Raffaella Parlato, Giuseppe Portale, Amalia M. Dolga & Patrick C. A. van der Wel

Journal: Nat Commun

PubMed ID: 40234398

Doi: 10.1038/s41467-025-58691-9

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Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses

Authors: Sebastian G. Huayamares, Liming Lian, Regina Rab, Yuning Hou, Afsane Radmand, Hyejin Kim, Ryan Zenhausern, Bhagelu R. Achyut, Melissa Gilbert Ross, Melissa P. Lokugamage, David Loughrey, Hannah E. Peck, Elisa Schrader Echeverri, Alejandro J. Da Silva Sanchez, Aram Shajii, Andrea Li, Karen E. Tiegreen, Philip J. Santangelo, Eric J. Sorscher & James E. Dahlman

Journal: Nature Communications

PubMed ID: 40221395

Doi: 10.1038/s41467-025-58548-1

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BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury

Authors: Wei Ruan, Tao Li, In Hyuk Bang, Jaewoong Lee, Wankun Deng, Xinxin Ma, Cong Luo, Fang Du, Seung-Hee Yoo, Boyun Kim, Jiwen Li, Xiaoyi Yuan, Katherine Figarella, Yu A. An, Yin-Ying Wang, Yafen Liang, Matthew DeBerge, Dongze Zhang, Zhen Zhou, Yanyu Wang, Joshua M. Gorham, Jonathan G. Seidman, Christine E. Seidman, Sary F. Aranki, …Holger K. Eltzschig

Journal: Nature

PubMed ID: 40269168

Doi: 10.1038/s41586-025-08898-z

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Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer

Authors: Tao Yuan, Yue Liu, Ruilin Wu, Meijia Qian, Weihua Wang, Yonghao Li, Hongdao Zhu, Jia’er Wang, Fujing Ge, Chenming Zeng, Xiaoyang Dai, Ronggui Hu, Tianhua Zhou, Qiaojun He, Hong Zhu & Bo Yang

Journal: Nature Communications

PubMed ID: 40240366

Doi: 10.1038/s41467-025-58923-y

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Vibrio MARTX toxin binding of biantennary N-glycans at host cell surfaces

Authors: Jiexi Chen, Felix Goerdeler, Thapakorn Jaroentomeechai, Francisco X S Hernandez, Xiaozhong Wang, Henrik Clausen, Yoshiki Narimatsu, Karla J F Satchell

Journal: SCIENCE ADVANCES

PubMed ID: 40203092

Doi: 10.1126/sciadv.adt0063

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The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization

Authors: Sarah Hamade, Melissa S Traver , Bonnie Bartel

Journal: Plant Direct

PubMed ID: 40212536

Doi: doi.org/10.1002/pld3.70054

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Citrulline regulates macrophage metabolism and inflammation to counter aging in mice

Authors: Zhangdan Xie, Moubin Lin, Beizi Xing, Hongmiao Wang, Haosong Zhang, Zimu Cai, Xinyu Mei, Zheng-Jiang Zhu

Journal: SCIENCE ADVANCES

PubMed ID: 40053596

Doi: 10.1126/sciadv.ads4957

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Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection

Authors: Yang Shi, Lin Wan, Mengmeng Jiao, Chuan-Qi Zhong, Huiting Cui, Jing Yuan

Journal: Nature Communications

PubMed ID: 40050296

Doi: 10.1038/s41467-025-57517-y

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The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro

Authors: Qingran Yang, Haoran Guo, Huili Li, Zhaoxue Li, Fushun Ni, Zhongmei Wen, Kai Liu, Huihui Kong, Wei Wei

Journal: Nature Communications

PubMed ID: 39962077

Doi: 10.1038/s41467-025-57094-0

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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin

Authors: Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee & Hyunju Cho

Journal: Nature Communications

PubMed ID: 39824813

Doi: 10.1038/s41467-025-56030-6

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