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Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

Authors: Nicolas O Jørgensen, Rasmus Kjøbsted, Magnus R Larsen, Jesper B Birk, Nicoline R Andersen, Bina Albuquerque, Peter Schjerling, Russell Miller, David Carling, Christian K Pehmøller, Jørgen F P Wojtaszewski

Journal: Mol Metab

PubMed ID: 34033941

Doi: 10.1016/j.molmet.2021.101259

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Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway

Authors: Xingchen Wu, Zhenyu Wang, Dan Qiao, Yu Yuan, Cong Han, Nan Yang, Ruizhen Li, Qian Du, Dewen Tong, Yong Huang

Journal: Vet Microbiol

PubMed ID: 33984793

Doi: 10.1016/j.vetmic.2021.109098

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The aminosterol Claramine inhibits β-secretase 1-mediated insulin receptor cleavage

Authors: Bénédicte Gaborit, Roland Govers, Alexandre Altié, Jean Michel Brunel, Pierre Morange, Franck Peiretti

Journal: J Biol Chem

PubMed ID: 34029592

Doi: 10.1016/j.jbc.2021.100818

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Open stomata 1 exhibits dual serine/threonine and tyrosine kinase activity in regulating ABA signaling

Authors: Yun Shang, Dami Yang, Yunmi Ha, Ju Yeon Lee, Jin Young Kim, Man-Ho Oh, Kyoung Hee Nam

Journal: J Exp Bot

PubMed ID: 34021330

Doi: 10.1093/jxb/erab225

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Etanercept Protected Against Cigarette Smoke Extract-Induced Inflammation and Apoptosis of Human Pulmonary Artery Endothelial Cells via Regulating TNFR1

Authors: Hong Xue, Baosong Xie, Nengluan Xu, Hongru Li, Qianshun Chen, Weiping Xie, Hong Wang

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 34007171

Doi: 10.2147/COPD.S295580

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Rituximab and Canakinumab Use During Lactation: No Detectable Serum Levels in Breastfed Infants

Authors: Nicole Bosshard, Astrid Zbinden, Klara Kristin Eriksson, Frauke Förger

Journal: Rheumatol Ther

PubMed ID: 33999372

Doi: 10.1007/s40744-021-00313-z

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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Authors: Kai Wen Teng, Steven T Tsai, Takamitsu Hattori, Carmine Fedele, Akiko Koide, Chao Yang, Xuben Hou, Yingkai Zhang, Benjamin G Neel, John P O'Bryan, Shohei Koide

Journal: Nat Commun

PubMed ID: 33976200

Doi: 10.1038/s41467-021-22969-5

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In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity

Authors: Lyndsay R Watkins, Cesare Orlandi

Journal: Br J Pharmacol

PubMed ID: 33784795

Doi: 10.1111/bph.15468

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Neither gonadotropin nor cumulus cell expansion is needed for the maturation of competent porcine oocytes in vitro

Authors: Bethany K Redel, Lee D Spate, Ye Yuan, Clifton N Murphy, R Michael Roberts, Randall S Prather

Journal: Biol Reprod

PubMed ID: 33962465

Doi: 10.1093/biolre/ioab090

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Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways

Authors: Tzyy-Bin Tsay, Wan-Hsuan Chang, Ching-Mei Hsu, Lee-Wei Chen

Journal: Respir Res

PubMed ID: 34022899

Doi: 10.1186/s12931-021-01739-3

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