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An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo

Authors: Xulun Zhang, Can Martin Zhang, Dmitry Prokopenko, Yingxia Liang, Sherri Y Zhen, Ian Q Weigle, Weinong Han, Manish Aryal, Rudolph E Tanzi, Sangram S Sisodia

Journal: J Exp Med

PubMed ID: 33822840

Doi: 10.1084/jem.20210313

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Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

Authors: Carmen Aguilar, Susana Costa, Claire Maudet, R P Vivek-Ananth, Sara Zaldívar-López, Juan J Garrido, Areejit Samal, Miguel Mano, Ana Eulalio

Journal: Nat Commun

PubMed ID: 34099666

Doi: 10.1038/s41467-021-23593-z

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The Breadth and Molecular Basis of Hcp-Driven Type VI Secretion System Effector Delivery

Authors: Sophie A Howard, R Christopher D Furniss, Dora Bonini, Himani Amin, Patricia Paracuellos, David Zlotkin, Tiago R D Costa, Asaf Levy, Despoina A I Mavridou, Alain Filloux

Journal: MBio

PubMed ID: 34061601

Doi: 10.1128/mBio.00262-21

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SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques

Authors: Carolina Garrido, Alan D Curtis, Maria Dennis, Sachi H Pathak, Hongmei Gao, David Montefiori, Mark Tomai, Christopher B Fox, Pamela A Kozlowski, Trevor Scobey, Jennifer E Munt, Michael L Mallory, Pooja T Saha, Michael G Hudgens, Lisa C Lindesmith, Ralph S Baric, Olubukola M Abiona, Barney Graham, Kizzmekia S Corbett, Darin Edwards, Andrea Carfi, Genevieve Fouda, Koen K A Van Rompay, Kristina De Paris, Sallie R Permar

Journal: Sci Immunol

PubMed ID: 34131024

Doi: 10.1126/sciimmunol.abj3684

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Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Authors: Jiajia Ma, Claire A Scott, Ying Na Ho, Harsha Mahabaleshwar, Katherine S Marsay, Changqing Zhang, Christopher Kj Teow, Ser Sue Ng, Weibin Zhang, Vinay Tergaonkar, Lynda J Partridge, Sudipto Roy, Enrique Amaya, Tom J Carney

Journal: Elife

PubMed ID: 34165081

Doi: 10.7554/eLife.66596

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CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B1351 SARS-CoV-2

Authors: Donata Hoffmann, Björn Corleis, Susanne Rauch, Nicole Roth, Janine Mühe, Nico Joel Halwe, Lorenz Ulrich, Charlie Fricke, Jacob Schön, Anna Kraft, Angele Breithaupt, Kerstin Wernike, Anna Michelitsch, Franziska Sick, Claudia Wylezich, Bernd Hoffmann, Moritz Thran, Andreas Thess, Stefan O Mueller, Thomas C Mettenleiter, Benjamin Petsch, Anca Dorhoi, Martin Beer

Journal: Nat Commun

PubMed ID: 34193869

Doi: 10.1038/s41467-021-24339-7

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Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

Authors: Gwo-Yu Chuang, Chen-Hsiang Shen, Crystal Sao-Fong Cheung, Jason Gorman, Adrian Creanga, M Gordon Joyce, Kwanyee Leung, Reda Rawi, Lingshu Wang, Eun Sung Yang, Yongping Yang, Baoshan Zhang, Yi Zhang, Masaru Kanekiyo, Tongqing Zhou, Brandon J DeKosky, Barney S Graham, John R Mascola, Peter D Kwong

Journal: Front Immunol

PubMed ID: 34135892

Doi: 10.3389/fimmu.2021.662909

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Open stomata 1 exhibits dual serine/threonine and tyrosine kinase activity in regulating ABA signaling

Authors: Yun Shang, Dami Yang, Yunmi Ha, Ju Yeon Lee, Jin Young Kim, Man-Ho Oh, Kyoung Hee Nam

Journal: J Exp Bot

PubMed ID: 34021330

Doi: 10.1093/jxb/erab225

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Etanercept Protected Against Cigarette Smoke Extract-Induced Inflammation and Apoptosis of Human Pulmonary Artery Endothelial Cells via Regulating TNFR1

Authors: Hong Xue, Baosong Xie, Nengluan Xu, Hongru Li, Qianshun Chen, Weiping Xie, Hong Wang

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 34007171

Doi: 10.2147/COPD.S295580

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Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y₁₂ signaling pathway

Authors: Huang B, Qian Y, Xie S, Ye X, Chen H, Chen Z, Zhang L, Xu J, Hu H, Ma S, Héroux P, Wang D, Shen HM, Wu Y, Xia D

Journal: Cellular & molecular immunology

PubMed ID: 32523112

Doi: 10.1038/s41423-020-0444-5

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