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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

Products & Services: Gene Synthesis Mutagenesis Services PCR Cloning and Subcloning Peptide Synthesis

Active- and Allosteric-Site Cyclic Peptide Inhibitors of Secreted M. tuberculosis Chorismate Mutase

Authors: Renier H P van Neer, Patricia K Dranchak, Mahesh Aitha, Lijun Liu, Emma K Carlson, Isabella E Jacobsen, Kevin Battaile, Yuhong Fang, Dingyin Tao, Ganesha Rai, Janak Padia, Scott Lovell, Hiroaki Suga, James Inglese

Journal: ACS Infectious Diseases

PubMed ID: 39903128

Doi: 10.1021/acsinfecdis.4c00798

Products & Services: Peptide Synthesis Plasmid DNA Preparation

Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

Authors: Charles Bou-Nader, Katie A Link, Krishna C Suddala, Jay R Knutson, Jinwei Zhang

Journal: Nature Communications

PubMed ID: 40050622

Doi: 10.1038/s41467-025-57519-w

Products & Services: Peptide Synthesis

Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis

Authors: Jitka Blazickova, Shalini Trivedi, Richard Bowman, Sowmya Sivakumar Geetha, Silma Subah, Michelle Scuzzarella, Alexander Chang, Uma R Chandran, Judith L Yanowitz, Sarit Smolikove, Verena Jantsch, Monique Zetka, Nicola Silva

Journal: Nature Communications

PubMed ID: 40082424

Doi: 10.1038/s41467-025-57862-y

Products & Services: Peptide Synthesis

Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

Authors: Jessica R Allanach, Naomi M Fettig, Blair K Hardman, Ariel R Rosen, Vina Fan, Cynthia Chung, Erin J Goldberg, Zachary J Morse, Iryna Shanina, Galina Vorobeychik, Lisa C Osborne, Marc S Horwitz

Journal: SCIENCE ADVANCES

PubMed ID: 40043135

Doi: 10.1126/sciadv.adu5110

Products & Services: Peptide Synthesis

Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

Products & Services: Peptide Synthesis

Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

Products & Services: Peptide Synthesis

Structures of HCoV-OC43 HR1 Domain in Complex with Cognate HR2 or Analogue EK1 Peptide

Authors: Xiuxiu He, Huanzhen Liu, Guang Yang, Lei Yan

Journal: Viruses-Basel

PubMed ID: 40143271

Doi: 10.3390/v17030343

Products & Services: Peptide Synthesis

The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat

Authors: Wen Yang, Man Feng, Kuohai Yu, Jie Cao, Guangxian Cui, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: Nature Communications

PubMed ID: 40000659

Doi: 10.1038/s41467-025-57291-x

Products & Services: Peptide Synthesis

CK2B Induces CD8+ T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer

Authors: Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun

Journal: Advanced Science

PubMed ID: 40013761

Doi: 10.1002/advs.202411053

Products & Services: Peptide Synthesis