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Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity

Authors: Regina S. Salvata , Deeptak Vermab , Andrew S. Parkerb , Jack R. Kirscha , Seth A. Brooksa,c, Chris Bailey-Kelloggb,d,e,, and Karl E. Griswolda,d,e,f,

Journal: PNAS Early Edition

Doi: 10.1073/pnas.1621233114

Products & Services: Peptide Synthesis

An essential role of high-molecular-weight kininogen in endotoxemia

Authors: Aizhen Yang, * Zhanli Xie, * Bo Wang, * Robert W. Colman, Jihong Dai,, and Yi Wu,

Journal: J. Exp. Med.

Doi: 10.1084/jem.20161900

Products & Services: Peptide Synthesis

TLR-induced murine dendritic cell (DC) activation requires DC-intrinsic complement

Authors: Joong-Hyuk Sheen, Michael G. Strainic, Jinbo Liu, WeijiaZhang, Zhengzi Yi, M. Edward Medof and Peter S. Heeger

Journal: The Journal of Immunology

Doi: 10.4049/jimmunol.1700339

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Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis

Authors: Jun Xiao, Run Jin, Xiang Yu, Max Shen, John D Wagner, Armaan Pai, Claire Song, Michael Zhuang, Samantha Klasfeld, Chongsheng He, Alexandre M Santos, Chris Helliwell, Jose L Pruneda-Paz, Steve A Kay, Xiaowei Lin, Sujuan Cui, Meilin Fernandez Garcia, Oliver Clarenz, Justin Goodrich, Xiaoyu Zhang, Ryan S Austin, Roberto Bonasio & Doris Wagner

Journal: Nature Genetics

Doi: 10.1105/tpc.16.00244 (2016)

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Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response.

Authors: Wei Junfei，Versteeg Leroy，Liu Zhuyun，Keegan Brian，Gazzinelli-Guimar?es Ana Clara，Fujiwara Ricardo T，Briggs Neima，Jones Kathryn M，Strych Ulrich，Beaumier Coreen M，Bottazzi Maria Elena，Hotez Peter J，Zhan

Journal: PLoS Negl Trop Dis

PubMed ID: 28708895

Doi: 10.1371/journal.pntd.0005769

Products & Services: Peptide Synthesis

The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation.

Authors: Rosenbaek Lena L，Rizzo Federica，Wu Qi，Rojas-Vega Lorena，Gamba Gerardo，MacAulay Nanna，Staub Olivier，Fenton Robe

Journal: Sci Rep

PubMed ID: 29021560

Doi: 10.1038/s41598-017-12819-0

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Authors: Moon Young-Mee，Lee Seon-Yeong，Kwok Seung-Ki，Lee Seung Hoon，Kim Deokhoon，Kim Woo Kyung，Her Yang-Mi，Son Hea-Jin，Kim Eun-Kyung，Ryu Jun-Geol，Seo Hyeon-Beom，Kwon Jeong-Eun，Hwang Sue-Yun，Youn Jeehee，Seong Rho H，Jue Dae-Myung，Park Sung-Hwan，Kim Ho-Youn，Ahn Sung-Min，Cho M

Journal: Front Immunol

PubMed ID: 29326694

Doi: 10.3389/fimmu.2017.01793

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Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses.

Authors: Zhao Jingxian，Alshukairi Abeer N，Baharoon Salim A，Ahmed Waleed A，Bokhari Ahmad A，Nehdi Atef M，Layqah Laila A，Alghamdi Mohammed G，Al Gethamy Manal M，Dada Ashraf M，Khalid Imran，Boujelal Mohamad，Al Johani Sameera M，Vogel Leatrice，Subbarao Kanta，Mangalam Ashutosh，Wu Chaorong，Ten Eyck Patrick，Perlman Stanley，Zhao Ji

Journal: Sci Immunol

PubMed ID: 28778905

Doi: 10.1126/sciimmunol.aan5393

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Peptide strand length controls the energetics of self-assembly and morphology of β-sheet fibrils.

Authors: Davies Robert P W，Liu Binbin，Maude Steven，Carrick Lisa M，Nyrkova Irina，McLeish Tom C，Harris Sar

Journal: Biopolymers

PubMed ID: 29127706

Doi: 10.1002/bip.23073

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A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer.

Authors: Martin Spencer D，Wick Darin A，Nielsen Julie S，Little Nicole，Holt Robert A，Nelson Br

Journal: Oncoimmunology

PubMed ID: 29296522

Doi: 10.1080/2162402X.2017.1371895

Products & Services: Peptide Synthesis