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Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros , Martin Wilkinson , Grigoria Tsaka , Meine Ramakers , Chiara Morelli , Teresa Garcia , Rodrigo Gallardo , Sam D'Haeyer , Vera Goossens , Dominique Audenaert , Dietmar Rudolf Thal , Ian R Mackenzie , Rosa Rademakers , Neil A Ranson , Sheena E Radford , Frederic Rousseau , Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 38310108

Doi: 10.1038/s41467-024-45429-2

Products & Services: Peptide Synthesis

PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

Authors: Paraskevi Tziortzouda , Jolien Steyaert , Wendy Scheveneels , Adria Sicart , Katarina Stoklund Dittlau , Adriana Margarida Barbosa Correia , Thibaut Burg , Arun Pal , Andreas Hermann , Philip Van Damme , Thomas G Moens , Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 38363426

Doi: 10.1007/s00401-024-02689-y

Products & Services: Peptide Synthesis

Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

Authors: Nayara Braga Emidio , Brandi M Small , Amanda R Keller , Ross W Cheloha , Laura M Wingler

Journal: Mol Pharmacol

PubMed ID: 38164609

Doi: 10.1124/molpharm.123.000797

Products & Services: Peptide Synthesis

ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Authors: Yongbing Yang , Yanan Wang , Zhongcheng Wang , Huanyu Yan , Yi Gong , Yingchao Hu , Yuying Jiang , Shuang Wen , Feifei Xu , Bingwei Wang , Fiachra Humphries , Yun Chen , Xi Wang , Shuo Yang

Journal: Nat Cell Biol .

PubMed ID: 38326554

Doi: 10.1038/s41556-024-01351-9

Products & Services: Peptide Synthesis

Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

Authors: Othman Baothman, Ehab M. M. Ali , Salman Hosawi , Emadeldin Hassan E. Konoz, Isam M. Abu Zeid, Abrar Ahmadand Hisham N. Altayb

Journal: Frontiers in pharmacology

Doi: 10.3389/fphar.2024.1322865

Products & Services: Peptide Synthesis

GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease

Authors: Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang, Bo Su

Journal: Biochim Biophys Acta Mol Basis Dis