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Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.

Authors: ShawSubrata，BianZhiguo，ZhaoBin，TarrJames C，VeerasamyNagarathanam，JeonKyu Ok，BelmarJohannes，ArnoldAllison L，FogartyStuart A，PerryEvan，SensintaffarJohn L，CamperDeMarco V，RossaneseOlivia W，LeeTaekyu，OlejniczakEdward T，FesikSteph

Journal: J. Med. Chem.

PubMed ID: 29323899

Doi: 10.1021/acs.jmedchem.7b01155

Products & Services: Peptide Synthesis

An F-type lectin domain directs the activity of Streptosporangium roseum alpha-L-fucosidase.

Authors: BishnoiRitika，MahajanSonal，RamyaT

Journal: Glycobiology

PubMed ID: 30169639

Doi: 10.1093/glycob/cwy079

Products & Services: Peptide Synthesis

TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.

Authors: DeshaiesJade-Emmanuelle，ShkretaLulzim，MoszczynskiAlexander J，SidibéHadjara，SemmlerSabrina，FouillenAurélien，BennettEstelle R，BekensteinUriya，DestroismaisonsLaurie，ToutantJohanne，DelmotteQuentin，VolkeningKathryn，StabileStéphanie，AulasAnaïs，KhalfallahYousra，SoreqHermona，NanciAntonio，StrongMichael J，ChabotBenoit，Vande VeldeChris

Journal: Brain

PubMed ID: 29562314

Doi: 10.1093/brain/awy062

Products & Services: Peptide Synthesis

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.

Authors: ChitiproluManeka，JagowChantal，TremblayVeronique，Bondy-ChorneyEmma，ParisGeneviève，SavardAlexandre，PalidworGareth，BarryFrancesca A，ZinmanLorne，KeithJulia，RogaevaEkaterina，RobertsonJanice，Lavallée-AdamMathieu，WoulfeJohn，CoutureJean-François，CôtéJocelyn，GibbingsDer

Journal: Nat Commun

PubMed ID: 30022074

Doi: 10.1038/s41467-018-05273-7

Products & Services: Peptide Synthesis

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.

Authors: MadiganJames P，HouFeng，YeLinlei，HuJicheng，DongAiping，TempelWolfram，YoheMarielle E，RandazzoPaul A，JenkinsLisa M Miller，GottesmanMichael M，TongYu

Journal: J. Biol. Chem.

PubMed ID: 30143532

Doi: 10.1074/jbc.RA118.003525

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Improving the Activity of Trp-Rich Antimicrobial Peptides by Arg/Lys Substitutions and Changing the Length of Cationic Residues.

Authors: AriasMauricio，PigaKathlyn B，HyndmanM Eric，VogelHa

Journal: Biomolecules

PubMed ID: 29671805

Doi: 10.3390/biom8020019

Products & Services: Peptide Synthesis

Protein Tyrosine Phosphatase-N13 (PTPN13) Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis.

Authors: BambergAlison，RedenteElizabeth F，GroshongSteve D，TuderRubin M，CoolCarlyne D，KeithRebecca C，EdelmanBenjamin L，BlackBart P，CosgroveGregory P，WynesMurry W，Curran-EverettDouglas，De LangheStijn，OrtizLuis A，ThorburnAndrew，RichesDavid

Journal: Am. J. Respir. Crit. Care Med.

PubMed ID: 29727583

Doi: 10.1164/rccm.201707-1497OC

Products & Services: Peptide Synthesis

Cell-Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis

Authors: Raju M, Santhoshkumar P, Sharma KK

Journal: Adv Biosyst.

PubMed ID: 30271873

Doi: 10.1002/adbi.201700095

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Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels.

Authors: MichalatouMichaila，AndroutsouMaria Eleni，AntonopoulosMarkos，VlahakosDemetrios V，AgelisGeorge，ZulliAnthony，QaradakhiTawar，MikkelsenKathleen，ApostolopoulosVasso，Matsoukas

Journal: Curr Mol Pharmacol

PubMed ID: 29676239

Doi: 10.2174/1874467211666180419152036

Products & Services: Peptide Synthesis

Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS.

Authors: GagnéJean-Philippe，LangelierMarie-France，PascalJohn M，PoirierG

Journal: J. Proteome Res.

PubMed ID: 29812941

Doi: 10.1021/acs.jproteome.8b00146

Products & Services: Peptide Synthesis