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A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.

Authors: SoChun，SeresK Bianka，SteyerAnna M，M?nnichEike，CliftDean，PejkovskaAnastasija，M?biusWiebke，SchuhMe

Journal: Science

PubMed ID: 31249032

Doi: 10.1126/science.aat9557

Products & Services: Peptide Synthesis

Tau local structure shields an?amyloid-forming motif and controls aggregation propensity.

Authors: ChenDailu，DromboskyKenneth W，HouZhiqiang，SariLevent，KashmerOmar M，RyderBryan D，PerezValerie A，WoodardDaNae R，LinMilo M，DiamondMarc I，JoachimiakLuka

Journal: Nat Commun

PubMed ID: 31175300

Doi: 10.1038/s41467-019-10355-1

Products & Services: Peptide Synthesis

The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif.

Authors: ChenMo，ChoiSuyong，JungOisun，WenTianmu，BaumChristina，ThapaNarendra，LambertPaul F，RapraegerAlan C，AndersonRicha

Journal: Sci Rep

PubMed ID: 31235839

Doi: 10.1038/s41598-019-45671-5

Products & Services: Peptide Synthesis

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin.

Authors: YeLiang，SchnepfDaniel，BeckerJan，EbertKarolina，TanriverYakup，BernasconiValentina，GadHans Henrik，HartmannRune，LyckeNils，StaeheliP

Journal: Nat. Immunol.

PubMed ID: 30886417

Doi: 10.1038/s41590-019-0345-x

Products & Services: Peptide Synthesis

CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells.

Authors: GaetePablo S，LilloMauricio A，PueblaMariela，PobleteInés，FigueroaXavi

Journal: Sci Rep

PubMed ID: 31138827

Doi: 10.1038/s41598-019-44333-w

Products & Services: Peptide Synthesis

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.

Authors: ShenKoning，GamerdingerMartin，ChanRebecca，GenseKarina，MartinEsther M，SachsNadine，KnightPatrick D，SchlömerRenate，CalabreseAntonio N，StewartKatie L，LeiendeckerLukas，BaghelAnkit，RadfordSheena E，FrydmanJudith，Deuerling

Journal: Mol. Cell

PubMed ID: 30982745

Doi: 10.1016/j.molcel.2019.03.012

Products & Services: Peptide Synthesis

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.

Authors: MeixiongJames，VasavdaChirag，SnyderSolomon H，DongXinz

Journal: Proc. Natl. Acad. Sci. U.S.A.

PubMed ID: 31068464

Doi: 10.1073/pnas.1903316116

Products & Services: Peptide Synthesis

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation.

Authors: JiaShang，HeDan，ChangChristoph

Journal: J. Am. Chem. Soc.

PubMed ID: 31017395

Doi: 10.1021/jacs.8b11912

Products & Services: Peptide Synthesis

Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines.

Authors: UmeshappaChannakeshava Sokke，SinghaSantiswarup，BlancoJesus，ShaoKun，NanjundappaRoopa Hebbandi，YamanouchiJun，ParésAlbert，SerraPau，YangYang，Santamaria

Journal: Nat Commun

PubMed ID: 31089130

Doi: 10.1038/s41467-019-09893-5

Products & Services: Peptide Synthesis

Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance.

Authors: LancasterJ N，ThyagarajanH M，SrinivasanJ，LiY，HuZ，EhrlichL

Journal: Nat Commun

PubMed ID: 31101805

Doi: 10.1038/s41467-019-09727-4

Products & Services: Peptide Synthesis