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Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion

Authors: Junwei Gao , Can Cao , Mingfei Shi , Shihao Hong , Shijie Guo , Jing Li , Tengxiao Liang , Ping Song , Ruodan Xu , Ning Li

Journal: Phytomedicine .

PubMed ID: 37421767

Doi: 10.1016/j.phymed.2023.154942

Products & Services: Peptide Synthesis Gene Synthesis

Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

Authors: Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He

Journal: Signal Transduct Target Ther

PubMed ID: 37743411

Doi: 10.1038/s41392-023-01630-1

Products & Services: Peptide Synthesis

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Authors: Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 37689716

Doi: 10.1038/s41467-023-41191-z

Products & Services: Peptide Synthesis

Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers

Authors: Caroline Koch, Benedict Reilly-O'Donnell, Richard Gutierrez, Carla Lucarelli, Fu Siong Ng, Julia Gorelik, Aleksandar P Ivanov, Joshua B Edel

Journal: Nat Nanotechnol

PubMed ID: 37749222

Doi: 10.1038/s41565-023-01479-z

Products & Services: Peptide Synthesis

An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses

Authors: Feifei Xiong, Chi Zhang, Baoyuan Shang, Mei Zheng, Qi Wang, Yahong Ding, Jian Luo, Xiuling Li

Journal: Emerg Microbes Infect

PubMed ID: 37671994

Doi: 10.1080/22221751.2023.2256422

Products & Services: Peptide Synthesis

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Authors: Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M Deane, Garrett M Morris, Shoumo Bhattacharya

Journal: Nat Commun

PubMed ID: 37717048

Doi: 10.1038/s41467-023-41488-z

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Adipose‑derived stem cell‑mediated alphastatin targeting delivery system inhibits angiogenesis and tumor growth in glioma

Authors: Chen Liang, Ting Wei, Ting Zhang, Chen Niu

Journal: Mol Med Rep

PubMed ID: 37772382

Doi: 10.3892/mmr.2023.13102

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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

Authors: Mark M Painter, Timothy S Johnston, Kendall A Lundgreen, Jefferson J S Santos, Juliana S Qin, Rishi R Goel, Sokratis A Apostolidis, Divij Mathew, Bria Fulmer, Justine C Williams, Michelle L McKeague, Ajinkya Pattekar, Ahmad Goode, Sean Nasta, Amy E Baxter, Josephine R Giles, Ashwin N Skelly, Laura E Felley, Maura McLaughlin, Joellen Weaver, Oliva Kuthuru, Jeanette Dougherty, Sharon Adamski, Sherea Long, Macy Kee, Cynthia Clendenin, Ricardo da Silva Antunes, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Alexander C Huang, Daniel J Rader, Scott E Hensley, Paul Bates, Allison R Greenplate, E John Wherry

Journal: Nat Immunol

PubMed ID: 37735592

Doi: 10.1038/s41590-023-01613-y

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Immature leaves are the dominant volatile-sensing organs of maize

Authors: Lei Wang, Simon Jäggi, Tristan M Cofer, Jamie M Waterman, Mario Walthert, Gaétan Glauser, Matthias Erb

Journal: Current Biology

PubMed ID: 37597519

Doi: 10.1016/j.cub.2023.07.045

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Genome characterization of the novel lytic phage vB_AbaAut_ChT04 and the antimicrobial activity of its lysin peptide against Acinetobacter baumannii isolates from different time periods

Authors: Udomluk Leungtongkam, Thawatchai Kitti, Supat Khongfak, Rapee Thummeepak, Kannipa Tasanapak, Jintana Wongwigkarn, Sophit Khanthawong, Aouatif Belkhiri, Henrique G Ribeiro, John S Turner, Danish J Malik, Sutthirat Sitthisak

Journal: Arch Virol

PubMed ID: 37660314

Doi: 10.1007/s00705-023-05862-y

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